Full-Length Enrich c-DNA Libraries-Clear Cell-Renal Cell Carcinoma
| Autor: | Sai-Wen Tang, Jung-Yaw Lin |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Kidney
cDNA library business.industry C-DNA Cancer Review Article Bioinformatics medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens urologic and male genital diseases lcsh:RC254-282 Metastasis Clear cell renal cell carcinoma medicine.anatomical_structure Oncology Gene expression Cancer research medicine business Survival rate |
| Zdroj: | Journal of Oncology Journal of Oncology, Vol 2012 (2012) |
| ISSN: | 1687-8469 |
| Popis: | Clear cell renal cell carcinoma (ccRCC), the most common subtype of RCC, is characterized by high metastasis potential and strong resistance to traditional therapies, resulting in a poor five-year survival rate of patients. Several therapies targeted to VEGF pathway for advanced RCC have been developed, however, it still needs to discover new therapeutic targets for treating RCC. Genome-wide gene expression analyses have been broadly used to identify unknown molecular mechanisms of cancer progression. Recently, we applied the oligo-capping method to construct the full-length cDNA libraries of ccRCC and adjacent normal kidney, and analyzed the gene expression profiles by high-throughput sequencing. This paper presents a review for recent findings on therapeutic potential of MYC pathway and nicotinamide N-methyltransferase for the treatment of RCC. |
| Databáze: | OpenAIRE |
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