Increased neural activity in transgenic mice with brain IGF-I overexpression
| Autor: | Fernando A. Barrios, L. Saum, Ali S. Calikoglu, Gabriel Gutiérrez-Ospina, Sofía Díaz-Cintra, A J D'Ercole |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Genetically modified mouse medicine.medical_specialty Ratón medicine.medical_treatment Transgene Central nervous system Mice Transgenic Nerve Tissue Proteins Deoxyglucose Biology Tritium Synaptic Transmission Mice Radioligand Assay Neurotrophic factors In vivo Internal medicine medicine Animals Insulin-Like Growth Factor I General Neuroscience Growth factor Wild type Brain Insulin-Like Growth Factor Binding Protein 1 Endocrinology medicine.anatomical_structure |
| Zdroj: | NeuroReport. 8:2907-2911 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-199709080-00021 |
| Popis: | To evaluate whether insulin-like growth factor-I (IGF-I) modulates neural activity in vivo, relative levels of brain [ 3 H]2-deoxyglucose (2DG) uptake were compared in adult behaving and anesthetized wild type (wt) mice, and transgenic (Tg) mice with either brain IGF-I overexpression or ectopic brain expression of IGF binding protein-1 (IGFBP-1). Overall, awake behaving IGF-I Tg mice showed significant increases in brain 2DG uptake compared with wt and IGFBP-1 Tg mice. These differences were eliminated after anesthesia. 2DG uptake was similar in awake behaving, and anesthetized wt and IGFBP-1 Tg mice. Our observations thus suggest that IGF-I increases neural activity levels in vivo, and that it is not involved in regulating glucose consumption in the adult brain. |
| Databáze: | OpenAIRE |
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