Splenectomy for Hematological Diseases: The Qatif Central Hospital Experience
| Autor: | Yassin M. Yassin, Syed Qaisaruddin, Zaki Naserullah, H Al Abkari, Ibrahim A. Al-Dabbous, Ali H. Al-Jam'a, Ahmed H. Al-Salem, Ahmed A. Al-Faraj |
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| Rok vydání: | 1999 |
| Předmět: | |
| Zdroj: | Annals of Saudi Medicine. 19:325-330 |
| ISSN: | 0975-4466 0256-4947 |
| DOI: | 10.5144/0256-4947.1999.325 |
| Popis: | In the Eastern Province of Saudi Arabia, an area known for various hemoglobinopathies, splenectomy is performed rather frequently. This study is an analysis of our experience with splenectomy performed for various hematological disorders between 1988 and 1997, outlining the indications, complications and outcome.This is a retrospective analysis of all patients who had splenectomy at our hospital during this period. One hundred and forty-three patients were treated for various hematological disorders at our hospital. These disorders included sickle cell disease (SCD) (100 patients), sickle ss-thalassemia (S-ss-thal) (13 patients), ss-thalassemia major (15 patients), Hb H disease (3 patients), idiopathic thrombocytopenic purpura (ITP) (5 patients), Gaucherâs disease (2 patients), hereditary spherocytosis (1 patient), autoimmune hemolytic anemia (1 patient), thalassemia intermediate (2 patients) and chronic myeloid leukemia (1 patient).The indications for splenectomy in those with SCD and S-ss-thal were: hypersplenism (26 patients), major splenic sequestration crisis (23 patients), minor recurrent splenic sequestration crisis (50 patients), splenic abscess (12 patients), and massive splenic infarction (2 patients). Splenectomy in these patients was beneficial in reducing their transfusion requirements and its attendant risks, eliminating the discomfort from mechanical pressure of the enlarged spleen, avoiding the risks of acute splenic sequestration crisis, and managing splenic abscess. For those with thalassemia, total splenectomy was beneficial in reducing their transfusion requirements, while partial splenectomy was beneficial only as a temporary measure, as regrowth of splenic remnant in these patients subsequently led to increase in their transfusion requirements. Those with ITP, hereditary spherocytosis, and autoimmune hemolytic anemia showed excellent response following splenectomy. There was no mortality, and the postoperative morbidity was 5.6%.With careful perioperative management, splenectomy is both safe and beneficial in a selected group of patients with hematological diseases. |
| Databáze: | OpenAIRE |
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