Antiplasmodial Diterpenoids from Psiadia arguta
| Autor: | Patricia Clerc, Sabina Jhaumeer-Laulloo, Olivia Jansen, Joyce Govinden Soulange, Keshika Mahadeo, Michel Frederich, Hippolyte Kodja, Isabelle Grondin, Gaëtan Herbette, Anne Gauvin-Bialecki |
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| Přispěvatelé: | Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments (LCSNSA), Université de La Réunion (UR), Spectropôle - Aix Marseille Université (AMU SPEC), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Laboratoire de pharmacognosie, Université de Liège, Laboratory of Pharmacognosy, Université de Liège-Natural and Synthetic Drugs Research Center, Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2019 |
| Předmět: |
Magnetic Resonance Spectroscopy
Spectrophotometry Infrared [SDV]Life Sciences [q-bio] Plasmodium falciparum Ethyl acetate Pharmaceutical Science Asteraceae 01 natural sciences Mass Spectrometry Analytical Chemistry Antimalarials chemistry.chemical_compound Drug Discovery Ic50 values Animals Formate Psiadia arguta Pharmacology Molecular Structure Strain (chemistry) Plant Extracts 010405 organic chemistry Chemistry Organic Chemistry 0104 chemical sciences 3. Good health Plant Leaves 010404 medicinal & biomolecular chemistry Complementary and alternative medicine Phytochemical Molecular Medicine Diterpenes Two-dimensional nuclear magnetic resonance spectroscopy Nuclear chemistry |
| Zdroj: | Journal of Natural Products Journal of Natural Products, American Chemical Society, 2019, 82 (5), pp.1361-1366. ⟨10.1021/acs.jnatprod.8b00698⟩ Journal of Natural Products, 2019, 82 (5), pp.1361-1366. ⟨10.1021/acs.jnatprod.8b00698⟩ |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.8b00698 |
| Popis: | International audience; An ethyl acetate extract of Psiadia arguta leaves showed in vitro antiplasmodial activity against Plasmodium falciparum with IC50 values of 12.3 ± 2.4 μg/mL (3D7 strain) and 13.5 ± 3.4 μg/mL (W2 strain). Phytochemical investigation led to the isolation and characterization of 16 compounds including four new diterpenoids: labdan-8α-ol-15-yl-(formate) (1), labdan-8α-ol-15-yl-(2-methylbutanoate) (2), labdan-8α-ol-15-yl-(3-methylpentanoate) (3), and labdan-8α-ol-15-yl-(labdanolate) (4). The latter compounds were characterized by spectroscopic methods (1D and 2D NMR, HRMS, and IR). The in vitro antiplasmodial activities of all compounds were evaluated. The known compounds labdan-13(E)-en-8α-ol-15-yl acetate (5), labdan-8α-ol-15-yl acetate (6), 13-epi-sclareol (7), labdan-13(E)-ene-8α,15-diol (8), and (8R,13S)-labdane-8α,15-diol (9) exhibited antiplasmodial effects, with IC50 values of 29.1, 33.2, 35.0, 36.6, and 22.2 μM, respectively. |
| Databáze: | OpenAIRE |
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