Metastatic chromophobe renal cell carcinoma in pleural fluid cytology: review of literature and report of a case
| Autor: | Peter Kulesza, Ritu Nayar, Simone Davion, Stephen M. Rohan |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Pathology medicine.medical_specialty Cytoplasm Histology Pleural effusion Chromophobe Renal Cell Carcinoma Chromophobe cell Piperazines Pathology and Forensic Medicine Metastasis Cytology Carcinoma medicine Humans Neoplasm Metastasis Carcinoma Renal Cell business.industry Cell Membrane General Medicine Middle Aged medicine.disease Immunohistochemistry Kidney Neoplasms Pleural Effusion Malignant Proto-Oncogene Proteins c-kit Imatinib mesylate Pyrimidines Benzamides Imatinib Mesylate Pleura business |
| Zdroj: | Diagnostic cytopathology. 40(9) |
| ISSN: | 1097-0339 |
| Popis: | The majority of chromophobe renal cell carcinomas (CHRCC) are not aggressive, however, a subset are. The potential for metastasis makes recognition of CHRCC cells in cytologic preparations important for patient surveillance, management, and treatment. We report the detection of an aggressive form of CHRCC in pleural fluid cytology with histopathologic confirmation on subsequent pleural biopsy. Sarcomatoid portions of the original CHRCC, and the pleural metastasis, demonstrated loss of diffuse membranous staining with C-KIT. |
| Databáze: | OpenAIRE |
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