Putative role of antireticulin antibody in antiacetylcholine-receptor-antibody-negative myasthenia gravis
| Autor: | Frits H. J. Gmelig Meyling, T. U. Hoogenraad |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty animal structures Neuromuscular transmission Disease Edrophonium chemistry.chemical_compound Arts and Humanities (miscellaneous) Immunopathology Myasthenia Gravis Medicine Humans Acetylcholine receptor Autoantibodies Autoimmune disease Reticuline biology business.industry Middle Aged musculoskeletal system medicine.disease Myasthenia gravis Reticulin chemistry Immunology biology.protein Prednisone Female Neurology (clinical) Antibody business Pyridostigmine Bromide |
| Zdroj: | Archives of neurology. 44(5) |
| ISSN: | 0003-9942 |
| Popis: | • It has recently been demonstrated that pathogenic immunoglobulins circulate in the blood of patients with acetylcholine-receptor-antibody (A-AChR)-negative myasthenia gravis (MG). Evidence has been presented that in this form of MG the neuromuscular transmission is impaired by antibodies that bind to end-plate determinants other than the AChR. We describe three patients with clinical manifestations of A-AChR—negative MG in whom antibody directed to reticulin (A-Ret) was detected. Antibody directed to reticulin is usually associated with celiac disease; however, none of the patients had symptoms or signs of celiac disease. To our knowledge, the association of A-Ret with A-AChR—negative MG has not been reported before. We postulate that A-Ret might help to differentiate between A-AChR-negative MG and congenital myasthenia. Further studies are needed to determine whether A-Ret plays a pathogenic role in A-AChR-negative MG or should instead be considered as an epiphenomenon. |
| Databáze: | OpenAIRE |
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