Single dose fosfomycin trometamol versus multiple dose norfloxacin over three days for uncomplicated UTI in general practice
| Autor: | Jozef Vandepitte, D Van Eyck, Joseph Reynaert |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Microbiology (medical)
Adult medicine.medical_specialty Time Factors Adolescent Urinary system Norfloxacin 400 MG Fosfomycin Multiple dose Drug Administration Schedule Internal medicine Cystitis medicine Escherichia coli Humans Norfloxacin Aged business.industry General Medicine biochemical phenomena metabolism and nutrition Middle Aged Surgery Fosfomycin trometamol Infectious Diseases Organization and Administration General practice Urinary Tract Infections Female business Standard therapy medicine.drug |
| Zdroj: | Infection. 18 |
| ISSN: | 0300-8126 |
| Popis: | The aim of this study was to carry out a small-scale bacteriological comparison between a standard therapy with norfloxacin 400 mg twice daily, and fosfomycin trometamol (3 g) in single dose in uncomplicated urinary tract infections (UTI) in women. Only patients with UTI with cultures showing a bacterial count of 10(5) or more bacteria/ml were included in the study (n = 32; ages 16-75 years). After one week sterile cultures were obtained in 14 of 16 cases in the fosfomycin trometamol group, and in 14 of 16 cases in the norfloxacin group. After one month eradication was confirmed in 13 of 16 patients in the fosfomycin trometamol group, and in nine of 16 patients in the norfloxacin group. Recurrence was seen in one case in the fosfomycin trometamol group, and in five cases in the norfloxacin group. The reinfection and persistence rates were identical (1/16) in both groups. The main clinical symptoms disappeared very rapidly after initiating treatment, and the correlation with the bacteriological data after one week was excellent. Both drugs were well tolerated and the compliance for fosfomycin trometamol was 100%. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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