| Autor: |
Lisa M. Butler, Andrew J. Hoy, Roger J. Daly, David J. Lynn, Max Moldovan, Shilpa R. Nagarajan, Elizabeth V. Nguyen, Julia S. Scott, Martin C. Sadowski, Swati Irani, Margaret M. Centenera, Chui Yan Mah, Zeyad D. Nassar |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1541-7786.22526834.v1 |
| Popis: |
Figure S1. AUY922 treatment induces the expression of proteins involved in fatty acid. metabolism and increases PCa cell mitochondrial mass and cellular ROS. Figure S2. Combination treatment of AUY922 with antagonists of fatty acid oxidation (FAO) and oxidative phosphorylation reveals functional interactions. Figure S3. AUY922 and PEX act synergistically on PCa cells. Figure S4. AUY922 and PEX act synergistically on PNT1 cells. Figure S5. PEX decreased fatty acid oxidation in AUY922 treated PCa cells. Figure S6. The effect of AUY922 and PEX combination treatment on AKT, ERK and S6 signaling pathways. Figure S7. AUY922 and PEX combination treatment induces apoptosis in 22RV1 and PNT1 cells. Figure S8. AUY922 and PEX combination treatment induces apoptosis in cultured primary prostate tumors. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
