Qingke β-glucan synergizes with a β-glucan-utilizing Lactobacillus strain to relieve capsaicin-induced gastrointestinal injury in mice
Autor: | Jinwei Xin, Hongwei Wang, Tian Tang, Huayi Suo, Yu Zhang, Jiajia Song |
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Rok vydání: | 2021 |
Předmět: |
Male
Lactobacillus strain Inflammation Gastrointestinal Injury macromolecular substances 02 engineering and technology Pharmacology Biochemistry Proinflammatory cytokine Mice 03 medical and health sciences chemistry.chemical_compound Structural Biology medicine Animals Gene Regulatory Networks Glucans Molecular Biology 030304 developmental biology Glucan chemistry.chemical_classification 0303 health sciences biology Plant Extracts Chemistry Probiotics Drug Synergism Hordeum General Medicine 021001 nanoscience & nanotechnology biology.organism_classification Combined Modality Therapy Gastroenteritis ErbB Receptors carbohydrates (lipids) Disease Models Animal stomatognathic diseases Treatment Outcome Gene Expression Regulation Capsaicin Zonula Occludens-1 Protein Cytokines medicine.symptom 0210 nano-technology Lactobacillus plantarum Hormone |
Zdroj: | International Journal of Biological Macromolecules. 174:289-299 |
ISSN: | 0141-8130 |
Popis: | Capsaicin (CAP) is the main pungent component in capsicum fruits. Eating too much CAP leads to gastrointestinal injury. Previously, Qingke β-glucan combined with β-glucan-utilizing Lactobacillus plantarum S58 (LP.S58) ameliorated high fat-diet-induced obesity, but their effects on CAP-induced gastrointestinal injury have not been investigated. Our results showed that Qingke β-glucan reduced the CAP-induced gastrointestinal injury in Kunming mice. The serum levels of inflammatory cytokines and gastrointestinal hormones, and the localized inflammation and the expression of EGF, EGFR, VEGF, and ZO-1 in the gastrointestinal tissues in CAP-treated mice were partly restored by Qingke β-glucan. The CAP-induced increase in the abundances of proinflammatory intestinal bacteria was also reduced by Qingke β-glucan. More importantly, we found that these beneficial effects of Qingke β-glucan were markedly enhanced by β-glucan-utilizing LP.S58 supplementation. Our study indicated that Qingke β-glucan coupled with β-glucan-utilizing LP.S58 relieved CAP-induced gastrointestinal injury. |
Databáze: | OpenAIRE |
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