Qingke β-glucan synergizes with a β-glucan-utilizing Lactobacillus strain to relieve capsaicin-induced gastrointestinal injury in mice

Autor: Jinwei Xin, Hongwei Wang, Tian Tang, Huayi Suo, Yu Zhang, Jiajia Song
Rok vydání: 2021
Předmět:
Male
Lactobacillus strain
Inflammation
Gastrointestinal Injury
macromolecular substances
02 engineering and technology
Pharmacology
Biochemistry
Proinflammatory cytokine
Mice
03 medical and health sciences
chemistry.chemical_compound
Structural Biology
medicine
Animals
Gene Regulatory Networks
Glucans
Molecular Biology
030304 developmental biology
Glucan
chemistry.chemical_classification
0303 health sciences
biology
Plant Extracts
Chemistry
Probiotics
Drug Synergism
Hordeum
General Medicine
021001 nanoscience & nanotechnology
biology.organism_classification
Combined Modality Therapy
Gastroenteritis
ErbB Receptors
carbohydrates (lipids)
Disease Models
Animal
stomatognathic diseases
Treatment Outcome
Gene Expression Regulation
Capsaicin
Zonula Occludens-1 Protein
Cytokines
medicine.symptom
0210 nano-technology
Lactobacillus plantarum
Hormone
Zdroj: International Journal of Biological Macromolecules. 174:289-299
ISSN: 0141-8130
Popis: Capsaicin (CAP) is the main pungent component in capsicum fruits. Eating too much CAP leads to gastrointestinal injury. Previously, Qingke β-glucan combined with β-glucan-utilizing Lactobacillus plantarum S58 (LP.S58) ameliorated high fat-diet-induced obesity, but their effects on CAP-induced gastrointestinal injury have not been investigated. Our results showed that Qingke β-glucan reduced the CAP-induced gastrointestinal injury in Kunming mice. The serum levels of inflammatory cytokines and gastrointestinal hormones, and the localized inflammation and the expression of EGF, EGFR, VEGF, and ZO-1 in the gastrointestinal tissues in CAP-treated mice were partly restored by Qingke β-glucan. The CAP-induced increase in the abundances of proinflammatory intestinal bacteria was also reduced by Qingke β-glucan. More importantly, we found that these beneficial effects of Qingke β-glucan were markedly enhanced by β-glucan-utilizing LP.S58 supplementation. Our study indicated that Qingke β-glucan coupled with β-glucan-utilizing LP.S58 relieved CAP-induced gastrointestinal injury.
Databáze: OpenAIRE
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