Increased plasma concentrations of intercellular adhesion molecule-1 after strenuous exercise associated with muscle damage
| Autor: | Makoto Saitoh, Takayuki Akimoto, Takahiro Waku, Koichi Sugiura, Takao Akama, Masahiro Furudate, Ichiro Kono |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Leukocyte migration Physiology Intercellular Adhesion Molecule-1 Motility Inflammation Physical exercise Running Oxygen Consumption Physiology (medical) Internal medicine medicine Humans Orthopedics and Sports Medicine Muscle Skeletal Exercise Myositis biology Chemistry Public Health Environmental and Occupational Health VO2 max General Medicine stomatognathic diseases Endocrinology Solubility Immunology Exercise Test Physical Endurance biology.protein Breathing Creatine kinase medicine.symptom |
| Zdroj: | European Journal of Applied Physiology. 86:185-190 |
| ISSN: | 1439-6327 1439-6319 |
| Popis: | Intercellular adhesion molecule-1 (ICAM-1) plays an important role in leukocyte migration from the circulation and intervention at sites of inflammation. We investigated the effects of various types of exercise on circulating levels of soluble ICAM-1 (sICAM-1) in normal healthy male adults. Plasma concentrations of sICAM-1 were measured before and after bicycle ergometer exercise at intensity of 80% maximal oxygen consumption ( $$ \dot V{\rm O}_{2\max } $$ ) (16 min), 42 km endurance running and 30-min downhill running at intensity of ventilation threshold (VT). The plasma sICAM-1 level increased 1 day after the endurance running (12%) and downhill running (14%), but not after ergometer exercise. Plasma C-reactive protein (CRP) and creatine kinase (CK) concentrations also increased 1 day after running. Our data suggest that exercise associated with muscle damage and/or inflammation results in increased levels of plasma sICAM-1. The physiological significance of post-exercise high plasma sICAM-1 levels is not clear at this stage, but changes in plasma sICAM-1 may reflect the status of the immune system. |
| Databáze: | OpenAIRE |
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