Association between admission hypothermia and outcomes in very low birth weight infants in China: a multicentre prospective study
| Autor: | Qiang Liu, Xiao-yang Huang, Fudong Peng, Ri-ming Zhao, Cong Li, Tong Chen, Yong-hui Yu, Li-ping Deng, Bing-ping Qiu, Yan-ling Gao, Mei-rong Bi, Xiu-fang Fan, Li-ling Wang, Min Geng, Xiu-xiang Liu, Ren-xia Zhu, Li Wang, Xue-yun Ren, Cheng-yuan Zhang, Ai-rong Sun, Yao Chen, Guo Yao, Huang Lei, Jing-cai Wu, Jing Li, Yanjie Ding, Yue-hua Zhao, Zhen-ying Yang, Shi-ping Niu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
China
Pediatrics medicine.medical_specialty Admission hypothermia medicine.medical_treatment Hypothermia 03 medical and health sciences 0302 clinical medicine Pregnancy Intensive Care Units Neonatal 030225 pediatrics Intensive care medicine Humans Infant Very Low Birth Weight Caesarean section Prospective Studies 030212 general & internal medicine Prospective cohort study Very low birth weight infants Outcome Neonatal sepsis Cesarean Section business.industry lcsh:RJ1-570 Infant Newborn Infant lcsh:Pediatrics medicine.disease Low birth weight Pediatrics Perinatology and Child Health Small for gestational age Female Apgar score Extremely low birth weight infants medicine.symptom business Infant Premature Research Article |
| Zdroj: | BMC Pediatrics BMC Pediatrics, Vol 20, Iss 1, Pp 1-9 (2020) |
| DOI: | 10.21203/rs.3.rs-16397/v1 |
| Popis: | BackgroundThe objective of this prospective, multicentre, observational cohort study was to evaluate the association between admission hypothermia and neonatal outcomes in very low-birth weight (VLBW) infants in multiple neonatal intensive care units (NICUs) in China.MethodsSince January 1, 2018, a neonatal homogeneous cooperative research platform-Shandong Neonatal Network (SNN) has been established. The platform collects clinical data in a prospective manner on preterm infants with birth weights (BWs) ResultsA total of 1247 VLBW infants were included in this analysis, of which 1100 infants (88.2%) were included in the hypothermia group, 554 infants (44.4%) in the mild hypothermia group and 546 infants (43.8%) in the moderate/severe hypothermia group. Small for gestational age (SGA), caesarean section, a low Apgar score at 5 min and intubation in the delivery room (DR) were related to admission hypothermia (AH). Mortality was the lowest when their admission temperature was 36.5 ~ 37.5 °C, and after adjustment for maternal and infant characteristics, mortality was significantly associated with AH. Compared with infants with normothermia (36.5 ~ 37.5 °C), the adjusted ORs of all deaths increased to 4.148 (95%CI1.505–11.437) and 1.806 (95%CI0.651–5.009) for infants with moderate/severe hypothermia and mild hypothermia, respectively. AH was also associated with a high likelihood of respiratory distress syndrome (RDS), intraventricular haemorrhage (IVH), and late-onset neonatal sepsis (LOS).ConclusionsAH is still very high in VLBW infants in NICUs in China. SGA, caesarean section, a low Apgar score at 5 min and intubation in the DR were associated with increased odds of hypothermia. Moderate/severe hypothermia was associated with mortality and poor outcomes, such as RDS, IVH, LOS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|