Implantable and Biodegradable Macroporous Iron Oxide Frameworks for Efficient Regeneration and Repair of Infracted Heart

Autor: Wenshuo Wang, Lai Wei, Biao Kong, Yun Zhao, Guanyu Yi, Jing Tang, Minglei Shu, Lei Wei, Jia Tang, Cordelia Selomulya, Jixue Zhou, Xiaotian Sun, Hongyue Tao, Yang Wang, Chunsheng Wang, Tianchan Chen
Rok vydání: 2016
Předmět:
medicine.medical_specialty
Materials science
food.ingredient
vasculature
Biocompatibility
Cell Survival
0206 medical engineering
Iron oxide
Myocardial Infarction
Medicine (miscellaneous)
Neovascularization
Physiologic
02 engineering and technology
Gelatin
Ferric Compounds
Hydrogel
Polyethylene Glycol Dimethacrylate
chemistry.chemical_compound
food
Highly porous
Absorbable Implants
medicine
blood iron pool
Animals
Regeneration
Viability assay
Pharmacology
Toxicology and Pharmaceutics (miscellaneous)
Cells
Cultured
Cell Proliferation
Matrigel
Regeneration (biology)
Mesenchymal Stem Cells
021001 nanoscience & nanotechnology
020601 biomedical engineering
Surgery
Rats
macroporous frameworks
stem cell
Disease Models
Animal
Treatment Outcome
chemistry
cardiac repair
Cardiac repair
0210 nano-technology
Biomedical engineering
Research Paper
Zdroj: Theranostics
ISSN: 1838-7640
Popis: The construction, characterization and surgical application of a multilayered iron oxide-based macroporous composite framework were reported in this study. The framework consisted of a highly porous iron oxide core, a gelatin-based hydrogel intermediary layer and a matrigel outer cover, which conferred a multitude of desirable properties including excellent biocompatibility, improved mechanical strength and controlled biodegradability. The large pore sizes and high extent of pore interconnectivity of the framework stimulated robust neovascularization and resulted in substantially better cell viability and proliferation as a result of improved transport efficiency for oxygen and nutrients. In addition, rat models with myocardial infraction showed sustained heart tissue regeneration over the infract region and significant improvement of cardiac functions following the surgical implantation of the framework. These results demonstrated that the current framework might hold great potential for cardiac repair in patients with myocardial infraction.
Databáze: OpenAIRE
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