Frontotemporal dementia: behavioral symptoms and caregiver distress
| Autor: | Hugo J. Duivenvoorden, J. C. van Swieten, J.C. Mourik, Sonia M. Rosso, Aad Tibben, Martinus F. Niermeijer |
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| Přispěvatelé: | Psychiatry, Neurology, Clinical Genetics |
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Cognitive Neuroscience Severity of Illness Index Degenerative disease Surveys and Questionnaires Severity of illness mental disorders medicine Aphasia Dementia Neurosensory disorders [UMCN 3.3] Humans Dementia diagnosis Psychiatry Psychomotor Agitation Aged Caregiver distress Depression Cognitive disorder nutritional and metabolic diseases Middle Aged medicine.disease Neuropsychiatric inventory Temporal Lobe nervous system diseases Frontal Lobe Psychiatry and Mental health Caregivers Female Geriatrics and Gerontology Psychology Frontotemporal dementia |
| Zdroj: | Dementia and Geriatric Cognitive Disorders, 18, 299-306 Dementia and Geriatric Cognitive Disorders, 18, 3-4, pp. 299-306 Dementia and Geriatric Cognitive Disorders, 18, 299-306. Karger |
| ISSN: | 1420-8008 |
| Popis: | Objective: To discern behavioral problems that co-occur in frontotemporal dementia (FTD) patients, and to investigate the relation between behavioral clusters and the burden for caregivers. Patients and Methods: Baseline data of 63 FTD patients and their respective caregivers were used to detect the behavioral clusters in the Neuropsychiatric Inventory (NPI) and the accompanying distress evoked in caregivers. To detect the clusters in behavior of the FTD patients, we performed multidimensional scaling (procedure: PROXSCAL). Multiple regression analysis was used to determine the association between behavior of patients and the distress experienced by caregivers. Results: This was the first study that found behavioral clusters for FTD. Two behavioral clusters were found: agitation/psychosis (comprising delusions, hallucinations, irritability and agitation) and mood (made up of anxiety and depression). The remaining NPI domains (euphoria, disinhibition, aberrant motor behavior and apathy were found to be autonomous. After controlling for relevant confounding factors, caregiver distress was strongest related to agitation/psychosis, followed by mood. Disinhibition and aberrant motor behavior were mildly related to caregiver distress. Euphoria and apathy were not significantly related to distress. Caregivers of patients living at home were more distressed by the behavioral problems of the FTD patients than caregivers of hospitalized patients. Discussion: The high prevalence of psychopathology in FTD patients and the associated caregiver distress was confirmed in this study. Clustering behavioral symptoms allows investigation of the relationship between structural or functional cerebral deficits and neuropsychiatric symptoms. |
| Databáze: | OpenAIRE |
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