Azadirachta indica A. Juss (neem) as a contraceptive: An evidence-based review on its pharmacological efficiency
| Autor: | Nagendra Prasad M N, Shashank M. Patil, Ramith Ramu, Chandana Kumari V B, Prithvi S. Shirahatti |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Phytochemicals Pharmaceutical Science Flowers 03 medical and health sciences 0302 clinical medicine Contraceptive Agents Drug Discovery Contraceptive Agents Female Animals Humans Medicine Spermatogenesis 030304 developmental biology Pharmacology Libido 0303 health sciences Azadirachta Evidence-Based Medicine Plants Medicinal Abortifacient Agents Traditional medicine biology Plant Extracts business.industry food and beverages Evidence based review biology.organism_classification Plant Leaves Systematic review Complementary and alternative medicine 030220 oncology & carcinogenesis Seeds Molecular Medicine Female business |
| Zdroj: | Phytomedicine. 88:153596 |
| ISSN: | 0944-7113 |
| Popis: | Background Azadirachta indica A. Juss. is an Indian medicinal plant with innumerable pharmacological properties. Studies have proven that the phytochemicals from neem possess remarkable contraceptive abilities with limited knowledge on its mechanism of action. Purpose The present review aims to summarize the efficiency of A. indica treatment as a contraceptive. Methods The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines were used. Published scientific articles on antifertility, antispermatogenic, antiovulation, hormone altering, contraceptive, and abortifacient activities of A. indica were collected from reputed Journals from 1980 to 2020 using electronic databases. Specific keywords search was completed to collect numerous articles with unique experiment design and significant results. This was followed by the selection of the requisite articles based on the criteria designed by the authors. Data extraction was based on the common research elements included in the articles. Results A total of 27 studies were considered for reviewing, which included key pharmacological investigations. In the beginning, authors evaluated a number of publications on the contraceptive properties of A. indica, in which it was revealed that most of the publications were made between 2005 and 2009. All the collected articles were categorised and reviewed as antifertility, antispermatogenic, antiovulation, hormone altering, contraceptive, and abortifacient. Authors also assessed studies based on the plant parts used for pharmacological evaluations including leaves, seeds, stem-bark, and flowers. The article was primarily divided into different sections based on the previous works of authors on phytochemistry and pharmacological review articles. Conclusion Although A. indica is not reported with the complete alleviation of reproductive system in both male and female animal models, studies have proven its efficacy as a contraceptive. Extracts and phytochemicals from neem neither reduced the libido nor retarded the growth of secondary sexual characters, thus indicating only a temporary and reversible contraceptive activity. However, there is a dearth for clinical studies to prove the efficacy of A. indica as a herbal contraceptive. |
| Databáze: | OpenAIRE |
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