The related miRNAs involved in doxorubicin resistance or sensitivity of various cancers: an update
| Autor: | Zahra Torki, Solmaz Hashemi, Yazdan Rahmati, Davood Ghavi, Majid Pornour, Mohammad Reza Alivand, Dara Rahmanpour |
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| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
DNA Repair DNA repair Apoptosis macromolecular substances Toxicology Cancer stem cell Neoplasms microRNA polycyclic compounds medicine Humans Pharmacology (medical) Doxorubicin Epithelial–mesenchymal transition Cell Proliferation Pharmacology Antibiotics Antineoplastic Cell growth business.industry organic chemicals technology industry and agriculture Cancer medicine.disease carbohydrates (lipids) Gene Expression Regulation Neoplastic MicroRNAs Oncology Drug Resistance Neoplasm Cancer cell Cancer research business medicine.drug |
| Zdroj: | Cancer chemotherapy and pharmacology. 88(5) |
| ISSN: | 1432-0843 |
| Popis: | Doxorubicin (DOX) is an effective chemotherapy agent against a wide variety of tumors. However, intrinsic or acquired resistance diminishes the sensitivity of cancer cells to DOX, which leads to a cancer relapse and treatment failure. Resolutions to this challenge includes identification of the molecular pathways underlying DOX sensitivity/resistance and the development of innovative techniques to boost DOX sensitivity. DOX is classified as a Topoisomerase II poison, which is cytotoxic to rapidly dividing tumor cells. Molecular mechanisms responsible for DOX resistance include effective DNA repair and resumption of cell proliferation, deregulated development of cancer stem cell and epithelial to mesenchymal transition, and modulation of programmed cell death. MicroRNAs (miRNAs) have been shown to potentiate the reversal of DOX resistance as they have gene-specific regulatory functions in DOX-responsive molecular pathways. Identifying the dysregulation patterns of miRNAs for specific tumors following treatment with DOX facilitates the development of novel combination therapies, such as nanoparticles harboring miRNA or miRNA inhibitors to eventually prevent DOX-induced chemoresistance. In this article, we summarize recent findings on the role of miRNAs underlying DOX sensitivity/resistance molecular pathways. Also, we provide latest strategies for utilizing deregulated miRNA patterns as biomarkers or miRNAs as tools to overcome chemoresistance and enhance patient's response to DOX treatment. |
| Databáze: | OpenAIRE |
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