Initial urinary epinephrine and cortisol levels predict acute PTSD symptoms in child trauma victims
| Autor: | Nicole R. Nugent, Michele C. Walsh, Douglas L. Delahanty, Norman C. Christopher |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
Child abuse medicine.medical_specialty Adolescent Epinephrine Hydrocortisone Dopamine Endocrinology Diabetes and Metabolism Urinary system Poison control Violence Severity of Illness Index Stress Disorders Post-Traumatic Norepinephrine Sex Factors Endocrinology Predictive Value of Tests Internal medicine Severity of illness medicine Humans Child Psychiatry Biological Psychiatry Depressive Disorder Endocrine and Autonomic Systems business.industry Trauma center Accidents Traffic medicine.disease Psychiatry and Mental health El Niño Athletic Injuries Wounds and Injuries Female business Anxiety disorder medicine.drug |
| Zdroj: | Psychoneuroendocrinology. 30:121-128 |
| ISSN: | 0306-4530 |
| DOI: | 10.1016/j.psyneuen.2004.06.004 |
| Popis: | Summary Background Previous research examining biological correlates of posttraumatic stress disorder (PTSD) in children has suggested that children with chronic PTSD have altered levels of catecholamines and cortisol compared to similarly traumatized children who do not meet diagnostic criteria. The present study extended these findings by examining whether urinary hormone levels collected soon after a trauma were related to subsequent acute PTSD symptoms in child trauma victims. Methods Initial 12-h urine samples were collected from 82 children aged 8–18 admitted to a Level 1 trauma center. Collection was begun immediately upon admission, and samples were assayed for levels of catecholamines and cortisol. PTSD and depressive symptomatology were assessed 6 weeks following the accident. Results Initial urinary cortisol levels were significantly correlated with subsequent acute PTSD symptoms (r=0.31). After removing the variance associated with demographic variables and depressive symptoms, urinary cortisol and epinephrine levels continued to predict a significant percentage (7–10%) of the variance in 6-week PTSD symptoms. Examination of boys and girls separately suggested that significance was primarily driven by the strength of the relationships between hormone levels and acute PTSD symptoms in boys. Conclusions The present findings suggest that high initial urinary cortisol and epinephrine levels immediately following a traumatic event may be associated with increased risk for the development of subsequent acute PTSD symptoms, especially in boys. |
| Databáze: | OpenAIRE |
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