Could the 185delAG BRCA1 Mutation Be an Ancient Jewish Mutation?
| Autor: | R B, Bar-Sade, L, Theodor, E, Gak, A, Kruglikova, G, Hirsch-Yechezkel, B, Modan, G, Kuperstein, U, Seligsohn, G, Rechavi, E, Friedman |
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| Rok vydání: | 1997 |
| Předmět: | |
| Zdroj: | European Journal of Human Genetics. 5:413-416 |
| ISSN: | 1476-5438 1018-4813 |
| DOI: | 10.1159/000484800 |
| Popis: | A predominant mutation within the BRCA1 predisposition gene, 185delAG, has been detected in about 1% of the Ashkenazi population, considered a high-risk group for breast and ovarian cancers. We examined 639 unrelated healthy Jews of Iraqi extraction, a presumed low-risk group, for the existence of this mutation. Three individuals were identified as 185delAG mutation carriers, and haplotype analysis of the Iraqi mutation carriers revealed that 2 of the Iraqis shared a common haplotype with 6 Ashkenazi mutation carriers, and 1 had a haplotype which differed by a single marker. This study suggests that the BRCA1 185delAG mutation also occurs in populations considered at low-risk for breast and ovarian cancers, and that it might have occurred prior to the dispersion of the Jewish people in the Diaspora, at least at the time of Christ. |
| Databáze: | OpenAIRE |
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