Seroprevalence of HCV, HBV and HIV in two inner-city London Emergency Departments
| Autor: | S. Dicks, Alison Rodger, L. Cieply, N. Ohemeng-Kumi, A. McGuinness, Henry W W Potts, Ruth Simmons, Edna Kara, J. Ledesma, S. Lattimore, William Rosenberg, Sema Mandal, S. Ijaz, Jean L. Mbisa |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Anonymous testing
Adult Male Hepatitis B virus HBsAg medicine.medical_specialty emergency department Adolescent Genotype HIV Antigens Epidemiology HIV Infections Hepacivirus HIV Antibodies Young Adult 03 medical and health sciences Underserved Population 0302 clinical medicine Seroepidemiologic Studies Internal medicine London medicine Humans Seroprevalence 030212 general & internal medicine Aged Aged 80 and over Original Paper Hepatitis B Surface Antigens business.industry HIV 030208 emergency & critical care medicine Odds ratio Hepatitis C Emergency department Hepatitis C Antibodies Middle Aged Hepatitis B medicine.disease Hospitals Confidence interval Infectious Diseases Female Emergency Service Hospital business |
| Zdroj: | Cieply, L, Simmons, R, Ijaz, S, Kara, E, Rodger, A, Rosenberg, W, McGuinness, A, Mbisa, J L, Ledesma, J, Ohemeng-Kumi, N, Dicks, S, Potts, H, Lattimore, S & Mandal, S 2019, ' Seroprevalence of HCV, HBV and HIV in two inner-city London Emergency Departments. ', Epidemiology and Infection, vol. 147, no. e145 . https://doi.org/10.1017/S0950268819000360 Epidemiology and Infection |
| DOI: | 10.1017/S0950268819000360 |
| Popis: | Summary: In this paper we build on work investigating the feasibility of human immunodeficiency virus (HIV) testing in emergency departments (EDs), estimating the prevalence of hepatitis B, C and HIV infections among persons attending two inner-London EDs, identifying factors associated with testing positive in an ED. We also undertook molecular characterisation to look at the diversity of the viruses circulating in these individuals, and the presence of clinically significant mutations which impact on treatment and control.Blood-borne virus (BBV) testing in non-traditional settings is feasible, with emergency departments (ED) potentially effective at reaching vulnerable and underserved populations. We investigated the feasibility of BBV testing within two inner-London EDs. Residual samples from biochemistry for adults (⩾18 years) attending The Royal Free London Hospital (RFLH) or the University College London Hospital (UCLH) ED between January and June 2015 were tested for human immunodeficiency virus (HIV)Ag/Ab, anti-hepatitis C (HCV) and HBsAg. PCR and sequence analysis were conducted on reactive samples. Sero-prevalence among persons attending RFH and UCLH with residual samples (1287 and 1546), respectively, were 1.1% and 1.0% for HBsAg, 1.6% and 2.3% for anti-HCV, 0.9% and 1.6% for HCV RNA, and 1.3% and 2.2% for HIV. For RFH, HBsAg positivity was more likely among persons of blackvs.white ethnicity (odds ratio 9.08; 95% confidence interval 2.72–30), with anti-HCV positivity less likely among females (0.15, 95% CI 0.04–0.50). For UCLH, HBsAg positivity was more likely among non-white ethnicity (13.34, 95% CI 2.20–80.86 (Asian); 8.03, 95% CI 1.12–57.61 (black); and 8.11, 95% CI 1.13–58.18 (other/mixed)). Anti-HCV positivity was more likely among 36–55 year oldsvs.⩾56 years (7.69, 95% CI 2.24–26.41), and less likely among females (0.24, 95% CI 0.09–0.65). Persons positive for HIV-markers were more likely to be of blackvs.white ethnicity (4.51, 95% CI 1.63–12.45), and less likely to have one ED attendance (0.39, 95% CI 0.17–0.88), or female (0.12, 95% CI 0.04–0.42). These results indicate that BBV-testing in EDs is feasible, providing a basis for further studies to explore provider and patient acceptability, referral into care and cost-effectiveness. |
| Databáze: | OpenAIRE |
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