Human Bone Marrow Adipose Tissue is a Metabolically Active and Insulin-Sensitive Distinct Fat Depot

Autor: Jarna C. Hannukainen, Keijo T Mäkelä, Sauli Piirola, Vesa Oikonen, Sven Enerbäck, Pirjo Nuutila, Tam Pham, Riku Kiviranta, Martin E. Lidell, Kirsi A. Virtanen, Riitta Parkkola, Kaisa K. Ivaska
Rok vydání: 2020
Předmět:
Adult
Male
medicine.medical_specialty
bone marrow
PET/CT
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Glucose uptake
Clinical Biochemistry
Adipose tissue
030209 endocrinology & metabolism
Context (language use)
White adipose tissue
Type 2 diabetes
Biochemistry
03 medical and health sciences
0302 clinical medicine
Endocrinology
Internal medicine
Adipocytes
medicine
Humans
Insulin
Longitudinal Studies
Obesity
030304 developmental biology
Clinical Research Article
0303 health sciences
business.industry
Biochemistry (medical)
Middle Aged
medicine.disease
Magnetic Resonance Imaging
adipose tissue
3. Good health
Cross-Sectional Studies
Glucose
medicine.anatomical_structure
Diabetes Mellitus
Type 2
Positron-Emission Tomography
Female
Bone marrow
Insulin Resistance
business
AcademicSubjects/MED00250
Zdroj: The Journal of Clinical Endocrinology and Metabolism
ISSN: 1945-7197
0021-972X
DOI: 10.1210/clinem/dgaa216
Popis: ContextBone marrow (BM) in adult long bones is rich in adipose tissue, but the functions of BM adipocytes are largely unknown. We set out to elucidate the metabolic and molecular characteristics of BM adipose tissue (BMAT) in humans.ObjectiveOur aim was to determine if BMAT is an insulin-sensitive tissue, and whether the insulin sensitivity is altered in obesity or type 2 diabetes (T2DM).DesignThis was a cross-sectional and longitudinal study.SettingThe study was conducted in a clinical research center.Patients or Other ParticipantsBone marrow adipose tissue glucose uptake (GU) was assessed in 23 morbidly obese subjects (9 with T2DM) and 9 healthy controls with normal body weight. In addition, GU was assessed in another 11 controls during cold exposure. Bone marrow adipose tissue samples for molecular analyses were collected from non-DM patients undergoing knee arthroplasty.Intervention(s)Obese subjects were assessed before and 6 months after bariatric surgery and controls at 1 time point.Main Outcome MeasureWe used positron emission tomography imaging with 2-[18F]fluoro-2-deoxy-D-glucose tracer to characterize GU in femoral and vertebral BMAT. Bone marrow adipose tissue molecular profile was assessed using quantitative RT-PCR.ResultsInsulin enhances GU in human BMAT. Femoral BMAT insulin sensitivity was impaired in obese patients with T2DM compared to controls, but it improved after bariatric surgery. Furthermore, gene expression analysis revealed that BMAT was distinct from brown and white adipose tissue.ConclusionsBone marrow adipose tissue is a metabolically active, insulin-sensitive and molecularly distinct fat depot that may play a role in whole body energy metabolism.
Databáze: OpenAIRE
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