Fabrication of non-dissolving analgesic suppositories using 3D printed moulds
| Autor: | Xucong Ruan, Guang Du, Yuanyuan Sun, Hairui Li, Lifeng Kang, Himanshu Kathuria |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Diclofenac
Materials science Fabrication Biocompatibility Chemistry Pharmaceutical Pharmaceutical Science Ibuprofen 02 engineering and technology Suppository Pharmacology Elastomer 030226 pharmacology & pharmacy Cell Line Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Silicone Elastic Modulus Tensile Strength Animals Anesthetics Local Dissolution chemistry.chemical_classification Analgesics Suppositories Anti-Inflammatory Agents Non-Steroidal Lidocaine Diclofenac Sodium Polymer 021001 nanoscience & nanotechnology Drug Liberation Solubility chemistry Ketoprofen Delayed-Action Preparations Printing Three-Dimensional Silicone Elastomers 0210 nano-technology Biomedical engineering |
| Zdroj: | International Journal of Pharmaceutics. 513:717-724 |
| ISSN: | 0378-5173 |
| Popis: | Conventional suppositories sometimes fail in exerting their therapeutic activity as the base materials melt inside body cavities. Also they are not suitable to provide long term treatment. Biomedical grade silicone elastomers may be used to fabricate non-dissolvable suppositories to overcome these disadvantages. We kneaded 4 analgesics into the 2 kinds of silicone polymers at 1%, 5% and 10% drug loading, respectively, to test their mechanical properties and drug release profiles. The optimized drug-polymer combinations were used to fabricate suppositories, and three dimensional printing (3DP) was used to create the suppository moulds. Subsequently, the drug release profiles and biocompatibility of the suppositories were studied. It was found that, the mechanical properties of the drug laden silicone elastomers and the rate of drug release from the elastomers can be tuned by varying drug-polymer combinations. The silicone elastomers containing 1% (w/w) and 5% (w/w) diclofenac sodium were the optimal formulations with prolonged drug release and biocompatibility at cellular level. These properties, together with complex geometries offered by 3DP technique, potentially made the non-dissolving suppositories promising therapeutic agents for personalized medicine. |
| Databáze: | OpenAIRE |
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