Role of gut-derived uremic toxins on oxidative stress and inflammation in patients with chronic kidney disease
| Autor: | P. V. L. N. Srinivasa Rao, S. Gouroju, Suchitra M. Manohar, Sivakumar Vishnubhotla, Kiranmayi S Vinapamula, Aparna R. Bitla |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
030232 urology & nephrology chemistry.chemical_element Inflammation 030204 cardiovascular system & hematology Calcium medicine.disease_cause lcsh:RC870-923 Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Medicine Bone mineral business.industry medicine.disease Malondialdehyde Cardiovascular disease risk lcsh:Diseases of the genitourinary system. Urology Ferric reducing ability of plasma chemistry Nephrology gut-derived uremic toxins Uric acid Original Article medicine.symptom business Oxidative stress chronic kidney disease Kidney disease |
| Zdroj: | Indian Journal of Nephrology, Vol 27, Iss 5, Pp 359-364 (2017) Indian Journal of Nephrology |
| ISSN: | 1998-3662 0971-4065 |
| Popis: | Several cardiovascular disease (CVD) risk factors have been identified among patients with chronic kidney disease (CKD). Gut-derived uremic toxins (GDUT) are important modifiable contributors in this respect. There are very few Indian studies on GDUT changes in CKD. One hundred and twenty patients older than 18 years diagnosed with CKD were enrolled along with forty healthy subjects. The patients were classified into three groups of forty patients based on stage of CKD. Indoxyl sulfate (IS), para cresyl sulfate (p-CS), indole acetic acid (IAA), and phenol were estimated along with the assessment of oxidative stress (OS), inflammatory state, and bone mineral disturbance. All the GDUT increased across the three groups of CKD. All patients had higher levels of malondialdehyde (MDA), ferric reducing ability of plasma (FRAP), high-sensitivity C-reactive protein (hsCRP), and interleukin-6 (IL-6) as compared to controls. IS and IAA showed positive association with MDA/FRAP corrected for uric acid, whereas IS and p-CS showed positive association with IL-6. IS, IAA, and phenol showed a positive association with calcium × phosphorus product. GDUT increase OS and inflammatory state in CKD and may contribute to CVD risk. |
| Databáze: | OpenAIRE |
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