Phenotype-genotype correlations of facial width and height proportions in patients with Class II malocclusion
| Autor: | Deborah V. Dawson, Thomas E. Southard, Derek R. Blanchette, L. M. Moreno Uribe, A. Ray |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Chin Adolescent Genotype Dentistry Orthodontics Single-nucleotide polymorphism Mandible Biology Malocclusion Angle Class II Nose Protein Serine-Threonine Kinases Eye Polymorphism Single Nucleotide Article Young Adult medicine Photography Lower face height Humans In patient Philtrum Principal Component Analysis Zygoma business.industry HMGA2 Protein Anatomic Variation Vertical Dimension LIM Domain Proteins Middle Aged Protein-Tyrosine Kinases medicine.disease Lip medicine.anatomical_structure Phenotype Otorhinolaryngology Face Principal component analysis Phenotype genotype Facial taper Surgery Female Oral Surgery Malocclusion business Orbit |
| Zdroj: | Orthodonticscraniofacial research. 18 |
| ISSN: | 1601-6343 |
| Popis: | Structured Abstract Objectives To characterize soft-tissue facial height and width variation in Class II malocclusion and test for correlations with genes HMGA2, AJUBA, and ADK. Setting and sample population Nine facial proportions were estimated from 2D frontal repose photographs of 330 Caucasian adults with Class II malocclusion. Material and methods After adjustments for age and gender, the facial proportions were submitted to a principal component analyses (PCA). The most meaningful phenotypic variations were correlated with SNPs rs7924176 (ADK), rs17101923 (HMGA2), and rs997154 (AJUBA) genotyped in 106 individuals. Results Principal component analyses resulted in four principal components (PCs), which explained 75% of total variation. PC1 captured variation in the intercanthus distance and explained 28% of total variation. PC2 explained 21% of the variations in facial taper and facial index. PC3 explained 14% and reflected variations in the vertical dimension of the lower face. PC4 explained 12% and captured variations in distance between the eyes, width of the commissures, and the length of the superior aspect of the lower face height corresponding to the vertical dimension of the philtrum of the upper lip. A suggestive association (p |
| Databáze: | OpenAIRE |
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