Acute Graft-versus-Host Disease Resulting from Normal Donor Blood Transfusions
| Autor: | Ray Tl, Westberg Mw, C. P. Burns, Lynell Warren Klassen, Goeken Ne, Burns Lj, Macfarlane De |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Graft vs Host Disease immune system diseases Blood product Antineoplastic Combined Chemotherapy Protocols medicine Humans Platelet Mechlorethamine Skin Chemotherapy medicine.diagnostic_test business.industry Histocompatibility Testing Transfusion Reaction Keratosis Hematology General Medicine medicine.disease Hodgkin Disease Rash Pancytopenia Surgery surgical procedures operative Graft-versus-host disease Vincristine Procarbazine Skin biopsy Prednisone Female medicine.symptom Packed red blood cells business |
| Zdroj: | Acta Haematologica. 71:270-276 |
| ISSN: | 1421-9662 0001-5792 |
| DOI: | 10.1159/000206599 |
| Popis: | 2 fatal cases of graft-versus-host disease (GvHD) occurred following blood product transfusions given to patients receiving standard chemotherapy for Hodgkin's disease. GvHD was established by HLA typing, clinical course, and compatible skin biopsy. 23 cases of GvHD following transfusion of blood products from normal donors are also reviewed. It should be suspected when fever or rash appear 1-2 weeks after transfusion of unirradiated blood products into a compromised host or when pancytopenia following chemotherapy is prolonged or unexpectedly severe. Prevention of GvHD by irradiation of granulocytes, platelets and packed red blood cells given to immunosuppressed patients is recommended to prevent this often fatal disease. |
| Databáze: | OpenAIRE |
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