Assays and reference materials for current and future applications of heparins
| Autor: | Barbara Mulloy, John Hogwood, Elaine Gray |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Glycan
medicine.drug_class Molecular Sequence Data Low molecular weight heparin Bioengineering Applied Microbiology and Biotechnology Anticoagulant activity medicine Animals Humans Blood Coagulation Pharmacology General Immunology and Microbiology biology Heparan sulphate Chemistry Heparin Heparin preparation In vitro toxicology Anticoagulants Biological activity General Medicine Reference Standards Biochemistry Carbohydrate Sequence biology.protein Biological Assay Heparitin Sulfate Biotechnology medicine.drug |
| Zdroj: | Biologicals : journal of the International Association of Biological Standardization. 38(4) |
| ISSN: | 1095-8320 |
| Popis: | Heparin is widely used in the prevention and treatment of thrombosis. However, this complex polysaccharide is biologically active in many systems other than coagulation, due to its structural similarity to the cell surface and matrix glycan heparan sulphate. These properties give rise to a number of potential therapeutic applications, such as those involving the anti-inflammatory activity of heparin. The anticoagulant activity of heparin is used to determine the potency of heparin preparations for use as antithrombotics. Several types of assay are used, and reference materials are available for their calibration. There is no equivalent measure of heparin's activity in other applications. For new types of heparin preparation, physicochemical methods of ensuring consistency and stability will be important, and new in vitro assays will have to be developed, all of which will require reference materials. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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