Mild hyponatremia as a risk factor for fractures: The rotterdam study
| Autor: | Bruno H. Stricker, M. Carola Zillikens, Ewout J. Hoorn, Robert Zietse, Huibert A. P. Pols, Joyce B. J. van Meurs, Fernando Rivadeneira, André G. Uitterlinden, Albert Hofman, Gijsbertus Ziere |
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| Přispěvatelé: | Internal Medicine, Epidemiology |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Bone density Endocrinology Diabetes and Metabolism Osteoporosis Population Kaplan-Meier Estimate Fractures Bone Rotterdam Study SDG 3 - Good Health and Well-being Bone Density Risk Factors Internal medicine medicine Humans Orthopedics and Sports Medicine Risk factor education Aged Netherlands education.field_of_study business.industry Sodium Hazard ratio nutritional and metabolic diseases Odds ratio medicine.disease Surgery Female business Hyponatremia Follow-Up Studies |
| Zdroj: | Journal of Bone and Mineral Research, 26(8), 1822-1828. Wiley-Blackwell |
| ISSN: | 0884-0431 |
| DOI: | 10.1002/jbmr.380 |
| Popis: | Recent studies suggest that mild hyponatremia is associated with fractures, but prospective studies are lacking. We studied whether hyponatremia is associated with fractures, falls, and/or bone mineral density (BMD). A total of 5208 elderly subjects with serum sodium assessed at baseline were included from the prospective population-based Rotterdam Study. The following data were analyzed: BMD, vertebral fractures (mean follow-up 6.4 years), nonvertebral fractures (7.4 years), recent falls, comorbidity, medication, and mortality. Hyponatremia was detected in 399 subjects (7.7%, 133.4 +/- 2.0 mmol/L). Subjects with hyponatremia were older (73.5 +/- 10.3 years versus 70.0 +/- 9.0 years, p |
| Databáze: | OpenAIRE |
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