Comparison of high-resolution magnification narrow-band imaging and white-light endoscopy in the prediction of histology in Barrett's oesophagus
| Autor: | Victoria Owen, Philip Kaye, Klara Garsed, Rajvinder Singh, Venkataraman Subramaniam, Edward Fogden, Haris Karageorgiou, Anthony Shonde, Paul J. Fortun, Krish Ragunath, Christopher J. Hawkey |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Light High resolution Magnification Sensitivity and Specificity Barrett Esophagus Esophagus Predictive Value of Tests Image Processing Computer-Assisted medicine Humans Prospective Studies Aged Aged 80 and over medicine.diagnostic_test business.industry Esophageal disease Gastroenterology Histology Middle Aged Image Enhancement medicine.disease Endoscopy Barrett's esophagus White light endoscopy Barrett's oesophagus Female Esophagoscopy business Nuclear medicine Precancerous Conditions |
| Zdroj: | Scandinavian Journal of Gastroenterology. 44:85-92 |
| ISSN: | 1502-7708 0036-5521 |
| Popis: | To evaluate whether there is any appreciable difference in imaging characteristics between high-resolution magnification white-light endoscopy (WLE-Z) and narrow-band imaging (NBI-Z) in Barrett's oesophagus (BE) and if this translates into superior prediction of histology.This was a prospective single-centre study involving 21 patients (75 areas, corresponding NBI-Z and WLE-Z images) with BE. Mucosal patterns (pit pattern and microvascular morphology) were evaluated for their image quality on a visual analogue scale (VAS) of 1-10 by five expert endoscopists. The endoscopists then predicted mucosal morphology based on four subtypes which can be visualized in BE. Type A: round pits, regular microvasculature; type B: villous/ridge pits, regular microvasculature; type C: absent pits, regular microvasculature; type D: distorted pits, irregular microvasculature. The sensitivity (Sn), specificity (Sp), positive predictive value (PPV), negative predictive value (NPV) and accuracy (Acc) were then compared with the final histopathological analysis and the interobserver variability calculated.The overall pit and microvasculature quality was significantly higher for NBI-Z, pit: NBI-Z=6, WLE-Z=4.5, p0.001; microvasculature: NBI-Z=7.3, WLE-Z=4.9, p0.001. This translated into a superior prediction of histology (Sn: NBI-Z: 88.9, WLE-Z: 71.9, p0.001). For the prediction of dysplasia, NBI-Z was superior to WLE-Z (chi(2)=10.3, p0.05). The overall kappa agreement among the five endoscopists for NBI-Z and WLE-Z, respectively, was 0.59 and 0.31 (p0.001).NBI-Z is superior to WLE-Z in the prediction of histology in BE, with good reproducibility. This novel imaging modality could be an important tool for surveillance of patients with BE. |
| Databáze: | OpenAIRE |
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