Isolated Neutropenia: An Unexplored Side Effect of Amiodarone

Autor:	David Peace, Hiren Patel
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Past medical history Isolated neutropenia business.industry Amiodarone Atrial fibrillation Case Report Neutropenia medicine.disease Discontinuation Anesthesia medicine Absolute neutrophil count Supratherapeutic level Voriconazole business Atrial flutter medicine.drug Grand mal seizure P450
Zdroj:	Journal of Medical Cases
ISSN:	1923-4163 1923-4155
Popis:	Amiodarone has been widely used for the treatment of various arrhythmias. It is a potent P450 inhibitor leading to interaction with many commonly prescribed drugs. Also, due to its long half-life, lipophilicity, and broad tissue distribution, it can cause a wide range of toxicities. A 62-year-old male with the unknown past medical history presented to the emergency department following a grand mal seizure. The patient initially presented with atrial flutter, which was controlled with beta blockers but was switched to amiodarone after 2 weeks when he developed atrial fibrillation with the rapid ventricular response. Approximately 1 month into his hospital stay, the patient developed severe isolated neutropenia. After ruling out other etiologies, amiodarone was withdrawn. The patient’s absolute neutrophil count recovered 3 days after discontinuation of amiodarone. J Med Cases. 2020;11(1):1-5 doi: https://doi.org/10.14740/jmc3394
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f94eaa9f8407c0054ab38e413c488a http://europepmc.org/articles/PMC8383674 Zobrazit plný text záznamu