Elevated corticosteroid levels block the memory-improving effects of nootropics and cholinomimetics
| Autor: | Cesare Mondadori, Thomas Ducret, A. Häusler |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Physostigmine Radioimmunoassay Pharmacology Mice chemistry.chemical_compound Adrenal Cortex Hormones Memory Corticosterone Internal medicine Memory improvement Avoidance Learning medicine Animals Oxiracetam Aldosterone Psychotropic Drugs Pramiracetam Piracetam Aniracetam Endocrinology Parasympathomimetics chemistry Tacrine Psychology medicine.drug |
| Zdroj: | Psychopharmacology. 108:11-15 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/bf02245278 |
| Popis: | Oral pretreatment of mice with aldosterone or corticosterone blocked the memory-enhancing effects of piracetam, pramiracetam, aniracetam and oxiracetam in a dose-related manner, without, however, impairing the animals' learning performance. The improvement of memory induced by physostigmine, arecoline, and tacrine (THA) was similarly inhibited. The fact that elevated steroid levels suppress the memory-enhancing effects of entirely different substances could indicate that these substances have a common site of action. In the light of new observations showing increased cortisol concentrations in Alzheimer patients, this steroid dependency of the effects of memory enhancers might explain why only a limited number of these patients respond to therapy with nootropics or cholinomimetics. |
| Databáze: | OpenAIRE |
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