Liver fluke (Fasciola hepatica)-derived peptides activate rat peritoneal mast cells
| Autor: | Alan Trudgett, Madeleine Ennis, A P Watt, Patrick Harriott |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Cell Degranulation
Immunology Neuraminidase Biology Histamine Release chemistry.chemical_compound Immune system Antigen parasitic diseases medicine Animals Immunology and Allergy Fasciola hepatica Mast Cells Peritoneal Cavity Pharmacology Dose-Response Relationship Drug Degranulation Mast cell biology.organism_classification Molecular biology N-Acetylneuraminic Acid Rats medicine.anatomical_structure Pertussis Toxin chemistry Cell culture Calcium Energy Metabolism Peptides Histamine |
| Zdroj: | International Immunopharmacology. 3:775-781 |
| ISSN: | 1567-5769 |
| Popis: | Short peptides with sequences derived from those found in the tegumental antigen of Fasciola hepatica have been synthesised. Incubation of some of these peptides with rat peritoneal mast cells resulted in the degranulation of the cells as measured by a histamine release assay. This activity was shown to be associated with the proline-lysine-proline motif, which is responsible for the induction of mast cell degranulation by the mammalian bioactive peptide substance P. Studies on the mode of action of the fluke-derived peptide indicated that it was operating through the same biochemical pathways as substance P. The implications of these findings for the development of immune responses during parasite infections are discussed. |
| Databáze: | OpenAIRE |
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