The sample that would not clot
| Autor: | Surabhi Palkimas, Sydney W. Strickland, Emily Burns, Lindsay A. L. Bazydlo |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
030213 general clinical medicine medicine.medical_specialty medicine.drug_class Clinical Biochemistry Antibiotics Biochemistry 03 medical and health sciences 0302 clinical medicine Internal medicine Vitamin K deficiency medicine Humans Dosing Blood Coagulation CYP2C9 Aged Automation Laboratory business.industry Biochemistry (medical) Warfarin Anticoagulants Thrombosis General Medicine medicine.disease Anti-Bacterial Agents Malnutrition 030104 developmental biology Endocrinology Female Vitamin K Deficiency business Protein C Pharmacogenetics medicine.drug |
| Zdroj: | Clinica Chimica Acta. 485:272-274 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2018.06.026 |
| Popis: | Background Vitamin K is a vital component within both the intrinsic and extrinsic coagulation cascade as certain factors (II, VII, IX, X and protein C and S) utilize vitamin K as a cofactor during post translational modification. Deficiency of vitamin K can result in the inability to properly form blood clots, both in vivo and in vitro, due to reduced vitamin K dependent factor levels and function. Vitamin K deficiency can result from congenital causes, such as VKOR or CYP2C9 mutations, or acquired causes, such as nutritional deficiencies, antibiotic therapy, or supra-therapeutic warfarin dosing. Results In this case we present a patient with multifactorial vitamin K deficiency (due to nutritional defects and multiple genetic mutations in VKOR and CYP2C9) that was exacerbated by antibiotic and warfarin therapy during her hospital admission. Conclusion This case displays the importance of genetic testing prior to warfarin dosing and the role antibiotics play in the coagulation cascade. |
| Databáze: | OpenAIRE |
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