Follistatin expression in the central nervous system of the adult rat
| Autor: | Chikara Ogawa, Yutaro Hayashi, Kanna Yamashita, Kazuma Masumoto, Fuminori Katou, Sumiko Mikawa, Kohji Sato |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male endocrine system Follistatin Ependymal Cell Central nervous system Biology 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine medicine Neuropil Animals Axon Rats Wistar Neurons Brain Epididymis Immunohistochemistry Axons Cell biology Rats Oligodendroglia 030104 developmental biology medicine.anatomical_structure Astrocytes embryonic structures biology.protein hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery Hormone |
| Zdroj: | Journal of chemical neuroanatomy. 105 |
| ISSN: | 1873-6300 |
| Popis: | Follistatin was initially cloned as a monomeric polypeptide that inhibits the release of follicle-stimulating hormone. Although follistatin also plays pivotal roles in skeletal muscle hypertrophy and immunoregulation in the epididymis, little information is available regarding follistatin function in the adult central nervous system (CNS). Hence, we investigated follistatin expression in the adult rat CNS using immunohistochemistry. Follistatin was intensely expressed in most neurons and their axons. Furthermore, oligodendrocytes, ependymal cells, and some astrocytes also expressed follistatin protein. These data indicate that follistatin is widely expressed throughout the adult CNS. The abundant expression of follistatin in the adult brain suggests that this protein plays important roles in the CNS. |
| Databáze: | OpenAIRE |
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