Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration?
| Autor: | Irwin K. Cheah, Keith Hsiu Chin Lim, Richard Ming Yi Tang, Barry Halliwell, Lei Feng |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Aging Biophysics Physiology Inflammation Biology medicine.disease_cause Risk Assessment Sensitivity and Specificity Biochemistry 03 medical and health sciences chemistry.chemical_compound Age Distribution Risk Factors medicine Humans Cognitive Dysfunction Risk factor Cognitive decline Molecular Biology Aged Whole blood Aged 80 and over Singapore Incidence Neurodegeneration Ergothioneine Reproducibility of Results Neurodegenerative Diseases Cell Biology Middle Aged medicine.disease 030104 developmental biology chemistry Ageing Female medicine.symptom Biomarkers Oxidative stress |
| Zdroj: | Biochemical and Biophysical Research Communications. 478:162-167 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2016.07.074 |
| Popis: | Ergothioneine (ET), a naturally occurring thione, can accumulate in the human body at high concentrations from diet. Following absorption via a specific transporter, OCTN1, ET may accumulate preferentially in tissues predisposed to higher levels of oxidative stress and inflammation. Given its potential cytoprotective effects, we examined how ET levels change with age. We found that whole blood ET levels in elderly individuals decline significantly beyond 60 years of age. Additionally, a subset of these subjects with mild cognitive impairment had significantly lower plasma ET levels compared with age-matched subjects. This decline suggests that deficiency in ET may be a risk factor, predisposing individuals to neurodegenerative diseases. |
| Databáze: | OpenAIRE |
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