LPS vs. Poly I:C Model
Autor: | Mian Bao, Naomi Hofsink, Torsten Plösch |
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Přispěvatelé: | Center for Liver, Digestive and Metabolic Diseases (CLDM), Reproductive Origins of Adult Health and Disease (ROAHD) |
Jazyk: | angličtina |
Rok vydání: | 2022 |
Předmět: |
Lipopolysaccharides
long-term outcome SARS-CoV-2 Physiology COVID-19 Lipopolysaccharide Review Bacterial Infections polyinosinic polycytidylic acid maternal infection Poly I-C Pregnancy Prenatal Exposure Delayed Effects Physiology (medical) Fetal programming polyinosinic:polycytidylic acid Humans Female |
Zdroj: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology American journal of physiology. Regulatory, Integrative and Comparative Physiology, 322(2). AMER PHYSIOLOGICAL SOC |
ISSN: | 1522-1490 |
DOI: | 10.1152/ajpregu.00087.2021 |
Popis: | A prominent health issue nowadays is the COVID-19 pandemic, which poses acute risks to human health. However, the long-term health consequences are largely unknown and cannot be neglected. An especially vulnerable period for infection is pregnancy, when infections could have long-term health effect on the child. Evidence suggests that maternal immune activation (MIA) induced by either bacteria or viruses presents various effects on the offspring, leading to adverse phenotypes in many organ systems. This review compares the mechanisms of bacterial and viral MIA and the possible long-term outcomes for the offspring by summarizing the outcome in animal LPS and Poly I:C models. Both models are activated immune responses mediated by Toll-like receptors. The outcomes for MIA offspring include neurodevelopment, immune response, circulation, metabolism, and reproduction. Some of these changes continue to exist until later life. Besides different doses and batches of LPS and Poly I:C, the injection day, administration route, and also different animal species influence the outcomes. Here, we specifically aim to support colleagues when choosing their animal models for future studies. |
Databáze: | OpenAIRE |
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