Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control
| Autor: | Bret F. Bessac, Sven-Eric Jordt |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Physiology
TRPV1 TRPV Cation Channels Nerve Tissue Proteins medicine.disease_cause Article chemistry.chemical_compound Transient receptor potential channel Transient Receptor Potential Channels Reflex medicine Animals Humans TRPA1 Cation Channel food and beverages respiratory system respiratory tract diseases Oxidative Stress Chronic cough Cough chemistry Capsaicin Anesthesia Immunology Calcium Channels Multiple Chemical Sensitivity Irritation medicine.symptom Airway psychological phenomena and processes |
| Zdroj: | Physiology. 23:360-370 |
| ISSN: | 1548-9221 1548-9213 |
| DOI: | 10.1152/physiol.00026.2008 |
| Popis: | New studies have revealed an essential role for TRPA1, a sensory neuronal TRP ion channel, in airway chemosensation and inflammation. TRPA1 is activated by chlorine, reactive oxygen species, and noxious constituents of smoke and smog, initiating irritation and airway reflex responses. Together with TRPV1, the capsaicin receptor, TRPA1 may contribute to chemical hypersensitivity, chronic cough, and airway inflammation in asthma, COPD, and reactive airway dysfunction syndrome. |
| Databáze: | OpenAIRE |
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