Detection and dynamics of anti‐platelet antibodies in thrombocytopenic dogs with and without idiopathic immune thrombocytopenia

Autor: Sarah B. Shropshire, Steven W. Dow, Michael R. Lappin
Rok vydání: 2020
Předmět:
Blood Platelets
Male
medicine.medical_specialty
040301 veterinary sciences
education
Standard Article
Disease
030204 cardiovascular system & hematology
Gastroenterology
0403 veterinary science
03 medical and health sciences
Dogs
0302 clinical medicine
immune system diseases
Melena
hemic and lymphatic diseases
Internal medicine
mental disorders
Animals
Medicine
Platelet
Dog Diseases
Autoantibodies
platelet
relapse
Purpura
Thrombocytopenic
Idiopathic
lcsh:Veterinary medicine
General Veterinary
biology
business.industry
flow cytometry
Repeated measures design
autoimmune
Hematology
04 agricultural and veterinary sciences
Odds ratio
Standard Articles
Exact test
Case-Control Studies
Etiology
biology.protein
lcsh:SF600-1100
Female
SMALL ANIMAL
medicine.symptom
Antibody
business
psychological phenomena and processes
Zdroj: Journal of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine, Vol 34, Iss 2, Pp 700-709 (2020)
ISSN: 1939-1676
0891-6640
DOI: 10.1111/jvim.15737
Popis: Background Antiplatelet antibodies are detected in multiple diseases including primary immune thrombocytopenia (ITP). Dynamics of how these antibodies change over time in ITP is unknown in dogs. Hypothesis/Objectives Antiplatelet antibodies (APA) will be detected in thrombocytopenic dogs with multiple etiologies and dynamics of APA in dogs with ITP can be used to evaluate response to treatment and relapse. Determine APA at the time of diagnosis in thrombocytopenic dogs and serially in primary ITP dogs. Animals Seventy‐nine thrombocytopenic dogs and 28 primary ITP dogs. Methods Direct flow cytometry was performed in thrombocytopenic dogs at initial evaluation and serially in suspected primary ITP dogs. In primary ITP dogs, a 2‐tailed Fisher's exact test was performed comparing survival to discharge between dogs with and without melena and to relate response to treatment and relapse to changes in APA and platelet count (repeated measures analysis, Spearman correlation). Results Twenty percent (16/79) of thrombocytopenic non‐ITP dogs with infectious, neoplastic, or other diseases and all primary ITP dogs were positive for APA. Melena at initial evaluation was associated with decreased survival to discharge (odds ratio 0.06; P = .01). Persistence of APA was not associated with response to treatment, but recurrence of antibodies was associated with relapse (odds ratio 205.0; P
Databáze: OpenAIRE
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