Variation in Inflammatory Biomarkers Among Demographic Groups Significantly Affects Their Accuracy in Diagnosing Periprosthetic Joint Infection
Autor: | Michael Yayac, Javad Parvizi, Fortunato G. Padua |
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Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Prosthesis-Related Infections Arthroplasty Replacement Hip Patient demographics Periprosthetic Blood Sedimentation Sensitivity and Specificity Serology 03 medical and health sciences 0302 clinical medicine Internal medicine Synovial Fluid Humans Medicine Orthopedics and Sports Medicine Medical diagnosis Arthroplasty Replacement Knee Demography 030222 orthopedics medicine.diagnostic_test biology business.industry C-reactive protein Inflammatory biomarkers C-Reactive Protein Erythrocyte sedimentation rate biology.protein Female business Body mass index Biomarkers |
Zdroj: | The Journal of Arthroplasty. 36:1420-1428 |
ISSN: | 0883-5403 |
Popis: | Background Diagnosis of periprosthetic joint infection (PJI) is a multistep process that involves performing various tests including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). The latter two tests, despite being used at all times for PJI diagnosis, are known to be nonspecific and substantially affected by demographic characteristics, including age, gender, race, and body mass index. It is unknown how these variations affect the diagnostic utility of serological markers for PJI. Methods Institutional databases were queried to identify patients undergoing revision arthroplasty between 2010 and 2018, in whom preoperative serum ESR and CRP was performed. Patient demographics were collected, and patients were cross-referenced with an internal database to determine their infection status. Analyses were performed to determine how ESR and CRP varied with respect to demographic factors, including age, gender, race, and infection status. Given that patient infection status was known at the time of revision, conclusions were drawn about the effect of these variations in inflammatory markers on the diagnostic utility of ESR and CRP. Results The value of ESR increased by age was higher in females and African American race. No significant differences were observed in the value of CRP among the demographic factors, although a slight positive trend was observed with respect to age. The variation in inflammatory markers significantly affected the sensitivity, specificity, and accuracy of ESR and CRP for PJI diagnosis. Conclusion Understanding how the accuracy of diagnostic tests varies with respect to demographic factors can help physicians avoid subjecting patients to unnecessary additional testing and reach more accurate diagnoses of PJI. |
Databáze: | OpenAIRE |
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