Parasympathetic dysautonomia precedes left ventricular systolic dysfunction in Chagas disease
| Autor: | Manoel Otávio da Costa Rocha, Enilce Oliveira, Antonio Luiz Pinho Ribeiro, Rosália Moraes Torres, Elton L. Ferlin, Ruy S. Moraes, Jorge Pinto Ribeiro |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Heart disease Systole Heart Ventricles Cardiomyopathy Ventricular Dysfunction Left Heart Rate Internal medicine Heart rate Humans Medicine Heart rate variability Chagas Disease Vagal tone Ejection fraction business.industry Dysautonomia Stroke Volume Vagus Nerve Middle Aged medicine.disease Echocardiography Doppler Circadian Rhythm Autonomic Nervous System Diseases Disease Progression Electrocardiography Ambulatory Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | American Heart Journal. 141:260-265 |
| ISSN: | 0002-8703 |
| Popis: | Background Parasympathetic dysautonomia is an established feature of advanced Chagas cardiomyopathy. However, in the absence of cardiac involvement, the presence of vagal dysfunction remains controversial. In a cross-sectional study, we compared patients with Chagas disease without cardiac involvement and healthy individuals by three different methods to determine whether vagal dysfunction is present in the early phase of Chagas disease. Methods Sixty-one patients with Chagas disease without cardiac involvement and 38 controls were submitted to respiratory sinus arrhythmia test and 24-hour Holter monitoring. Vagal heart influences were assessed by the expiratory/inspiratory (E/I) ratio, time-domain indexes of heart rate variability (HRV), and by the quantification of a 3-dimensional return map. Results The two groups were comparable in terms of left ventricular ejection fraction and left ventricular end-diastolic dimension. Compared with the control group, patients with Chagas disease had significantly lower values of the E/I ratio (mean ± SD: 1.38 ± 0.02 and 1.25 ± 0.02, P |
| Databáze: | OpenAIRE |
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