Centrosome-dependent asymmetric inheritance of the midbody ring inDrosophilagermline stem cell division
| Autor: | Viktoria Salzmann, Cuie Chen, Yukiko M. Yamashita, Amita Tiyaboonchai, Ason C.Y. Chiang, Michael Mayer |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Centrosome
endocrine system Cell division Cellular differentiation fungi Cell Differentiation Centrosome cycle Articles Spindle Apparatus Cell Biology Biology Cell biology Adult Stem Cells Stem cell division Chromosome Segregation Animals Drosophila Stem cell 10. No inequality Molecular Biology Cytoskeleton Cell Division Cytokinesis Adult stem cell |
| Zdroj: | Molecular Biology of the Cell |
| ISSN: | 1939-4586 1059-1524 |
| DOI: | 10.1091/mbc.e13-09-0541 |
| Popis: | The midbody ring (MR) is asymmetrically segregated during asymmetric divisions of germline stem cells (GSCs) in Drosophila. Male GSCs, which inherit the mother centrosome, exclude the MR, whereas female GSCs, which inherit the daughter centrosome, inherit the MR. Moreover, stem cell identity correlates with the mode of MR inheritance. Many stem cells, including Drosophila germline stem cells (GSCs), divide asymmetrically, producing one stem cell and one differentiating daughter. Cytokinesis is often asymmetric, in that only one daughter cell inherits the midbody ring (MR) upon completion of abscission even in apparently symmetrically dividing cells. However, whether the asymmetry in cytokinesis correlates with cell fate or has functional relevance has been poorly explored. Here we show that the MR is asymmetrically segregated during GSC divisions in a centrosome age–dependent manner: male GSCs, which inherit the mother centrosome, exclude the MR, whereas female GSCs, which we here show inherit the daughter centrosome, inherit the MR. We further show that stem cell identity correlates with the mode of MR inheritance. Together our data suggest that the MR does not inherently dictate stem cell identity, although its stereotypical inheritance is under the control of stemness and potentially provides a platform for asymmetric segregation of certain factors. |
| Databáze: | OpenAIRE |
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