| Autor: |
Luca Toti, A. De Rossi, Salvatore Gruttadauria, A.D. Pinna, Giovanni Fantola, Francesca D’Arcangelo, Alberto Ferrarese, Giovanni Vennarecci, Sarah Shalaby, Diego Serraino, Pierluca Piselli, Fausto Zamboni, Martina Taborelli, Umberto Cillo, Marco Senzolo, Maria Rendina, Patrizia Burra, Martina Gambato, Alberto Zanetto, Massimo Rossi, Augusto Lauro, L. Galatioto, Patrizia Boccagni, Giuseppe Tisone, Francesco Nudo, Federico Russo, Andrea Risaliti, Giuseppe Maria Ettorre, A. Di Leo, Giacomo Germani, Raffaella Petrara, Umberto Baccarani |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Popis: |
Patients with hepatocellular carcinoma (HCC) are at high risk of second primary malignancies. As HCC has become the leading indication of liver transplant (LT), the aim of this study was to investigate whether the presence of HCC before LT could influence the onset of de novo malignancies (DNM). A cohort study was conducted on 2653 LT recipients. Hazard ratios (HR) of DNM development for patients transplanted for HCC (HCC patients) were compared with those of patients without any previous malignancy (non-HCC patients). All models were adjusted for sex, age, calendar year at transplant, and liver disease etiology. Throughout 17 903 person-years, 6.6% of HCC patients and 7.4% of non-HCC patients developed DNM (202 cases). The median time from LT to first DNM diagnosis was shorter for solid tumors in HCC patients (2.7 vs 4.5 years for HCC and non-HCC patients, respectively, P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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