Survival Outcome of Squamous Cell Carcinoma Arising from Sinonasal Inverted Papilloma
| Autor: | Qing-Zhuang Liang, Dezhi Li, Hui Huang, Yuehuang Wu, Xiaolei Wang, Zhengang Xu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Adolescent lcsh:Medicine Sinonasal Inverted Papilloma Squamous Cell Carcinoma Survival Outcome Malignancy Benign tumor Young Adult Internal medicine medicine Carcinoma Humans Stage (cooking) Survival rate Aged Retrospective Studies Aged 80 and over Papilloma Inverted business.industry lcsh:R Retrospective cohort study General Medicine Middle Aged medicine.disease Surgery Paranasal sinuses medicine.anatomical_structure Multivariate Analysis Carcinoma Squamous Cell Papilloma Original Article Female business |
| Zdroj: | Chinese Medical Journal Chinese Medical Journal, Vol 128, Iss 18, Pp 2457-2461 (2015) |
| ISSN: | 0366-6999 |
| Popis: | Background: Sinonasal inverted papilloma (IP) is a rare benign tumor of the nasal cavities and paranasal sinuses. It is destructive or bone-remodeling, tends to recur after surgical resection, and has a significant malignant potential. The present study aimed to perform a retrospective analysis of patients with squamous cell carcinoma (SCC) arising from IP, including characteristics, survival outcome, and predictors of associated malignancy. Methods: The medical records of 213 patients diagnosed with IP from January 1970 to January 2014 were retrospectively reviewed. Eighty-seven patients were diagnosed with SCC/IP; their clinical characteristics, treatments, and survival outcomes were analyzed. Results: Of the 87 patients with SCC/IP, the 5- and 10-year overall survival outcomes were 39.6% and 31.8%, respectively. Twenty-nine of these patients received surgery and 58 received combined surgery and radiation. Of the patients with stages III-IV, the 5-year survival rate was 30.7% for those treated with surgery only and 39.9% for those given the combination treatment ( P = 0.849). Factors associated with significantly poor prognosis were advanced-stage, metachronous tumors, or with cranial base and orbit invasion. Age, synchronous or metachronous tumors, and pathological stage were independent risk factors for mortality, shown by multivariate analysis. Conclusion: Patients with SCC/IP had low overall survival outcomes. Advanced age, stage, and metachronous tumors are the main factors affecting prognosis. Treatment planning should consider high-risk factors to improve survival outcome. |
| Databáze: | OpenAIRE |
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