Effect of Coenzyme Q10 on Expression of UbiAd1 Gene in Rat Model of Local Cerebral Ischemia
| Autor: | Alexander V. Balatsky, V S Gusakov, Medvedev Os, O. V. Povarova |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Antioxidant Ubiquinone medicine.medical_treatment Intraperitoneal injection Ischemia Endogeny Pharmacology Neuroprotection General Biochemistry Genetics and Molecular Biology Brain Ischemia 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine.artery medicine Animals Coenzyme Q10 Messenger RNA Chemistry Cerebral Infarction General Medicine Dimethylallyltranstransferase medicine.disease Rats Neuroprotective Agents 030104 developmental biology Middle cerebral artery 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 165:69-71 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | The study examined the effect of endogenous lipid-soluble antioxidant coenzyme Q10 on the expression of UbiA gene of prenyltransferase domain-containing protein 1 (UbiAd1) involved in synthesis of vitamin K2 (and probably of coenzyme Q10) on a rat model of ischemic stroke provoked by ligation of the middle cerebral artery in the left hemisphere. Ischemia enhanced expression of mRNA of UbiAd1 gene in both cerebral hemispheres, but the effect was significant only in the contralateral one. The study revealed no effect of intraperitoneal injection of coenzyme Q10 (30 mg/kg) on ischemia-produced elevation of mRNA of UbiAd1 gene. Further studies are needed to assess possible neuroprotective effects of antioxidant coenzyme Q10. |
| Databáze: | OpenAIRE |
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