Sesame lignan sesamol protects against aspirin-induced gastric mucosal damage in rats
| Autor: | Victor Raj Mohan Chandrasekaran, Dur Zong Hsu, Ming Yie Liu, Pei Yi Chu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Medicine (miscellaneous)
Inflammation Pharmacology medicine.disease_cause Proinflammatory cytokine Lipid peroxidation chemistry.chemical_compound Gastric mucosa Medicine TX341-641 Sesamol Neutrophil infiltration Aspirin Gastric mucosa injury Nutrition and Dietetics biology business.industry Nutrition. Foods and food supply digestive oral and skin physiology digestive system diseases medicine.anatomical_structure chemistry Oxidative stress Myeloperoxidase Immunology biology.protein medicine.symptom business Food Science medicine.drug |
| Zdroj: | Journal of Functional Foods, Vol 1, Iss 4, Pp 349-355 (2009) |
| ISSN: | 1756-4646 |
| Popis: | Non-steroidal anti-inflammatory drugs are commonly used to control pain, fever, and various inflammatory diseases; however, they have been identified as gastro-toxic. The aim of the present study was to evaluate the effect of aspirin plus sesamol on gastric mucosa in rats. Rats were given oral aspirin (30 mg/kg/d) and oral sesamol (ranging from 0 to 30 mg/kg/day) for 5 weeks, after which their gastric mucosal integrity, oxidative stress, inflammation, and neutrophil infiltration were assessed 6 h after gastric surgery. Sesamol dose-dependently decreased aspirin-induced gastric haemorrhage and mucosal ulceration, and significantly reduced (a) gastric mucosal lipid peroxidation, (b) nitric oxide production, (c) gastric mucosal proinflammatory cytokines (tumor necrosis factor-α and interleukin 1-β levels), and (d) the activity of gastric mucosal myeloperoxidase compared with aspirin-alone groups. We hypothesize that aspirin plus sesamol decreases aspirin-induced gastro-toxicity by inhibiting neutrophil infiltration and subsequent gastric mucosal inflammation and oxidative stress in rats. |
| Databáze: | OpenAIRE |
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