Differential effects on out-of-hospital cardiac arrest of dihydropyridines:real-world data from population-based cohorts across two European countries

Autor: Marieke T. Blom, Anthonius de Boer, Arie O. Verkerk, Patrick C. Souverein, Fredrik Folke, Hanno L. Tan, G H Mohr, Talip E Eroglu, Richard P. Davis, Mads Wissenberg, Lettine van den Brink, Gunnar Gislason, Christian Torp-Pedersen
Přispěvatelé: Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Cardiology, Graduate School, ACS - Heart failure & arrhythmias, Medical Biology, Amsterdam Cardiovascular Sciences, APH - Methodology, APH - Health Behaviors & Chronic Diseases
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
drug megadose
induced pluripotent stem cell
endogenous compound
Epidemiology
Denmark
Action Potentials
030204 cardiovascular system & hematology
Ventricular tachycardia
low drug dose
0302 clinical medicine
action potential
Risk Factors
Medicine
Pharmacology (medical)
Myocytes
Cardiac
AcademicSubjects/MED00200
030212 general & internal medicine
Registries
calcium current
Cells
Cultured
Netherlands
education.field_of_study
cardiac muscle cell
patch clamp technique
Cardiac electrophysiology
heart electrophysiology
adult
Sudden cardiac arrest
Nifedipine
Amlodipine
drug effect
Arrhythmia/Electrophysiology
article
titrimetry
Middle Aged
Calcium Channel Blockers
3. Good health
female
cardiovascular system
Cardiology
AcademicSubjects/MED00410
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
medicine.drug
medicine.medical_specialty
dihydropyridine
out of hospital cardiac arrest
Population
Induced Pluripotent Stem Cells
heart
Risk Assessment
sudden cardiac death
03 medical and health sciences
male
Internal medicine
calcium channel L type
Humans
controlled study
Calcium Signaling
human
out-of-hospital cardiac arrest
education
Aged
Retrospective Studies
Fibrillation
Dose-Response Relationship
Drug
business.industry
human cell
Odds ratio
Original Articles
case control study
nitric acid derivative
medicine.disease
ischemic heart disease
major clinical study
heart ventricle tachycardia
business
Out-of-Hospital Cardiac Arrest
Zdroj: Eroglu, T E, Mohr, G H, Blom, M T, Verkerk, A O, Souverein, P C, Torp-Pedersen, C, Folke, F, Wissenberg, M, Van Den Brink, L, Davis, R P, De Boer, A, Gislason, G H & Tan, H L 2020, ' Differential effects on out-of-hospital cardiac arrest of dihydropyridines : real-world data from population-based cohorts across two European countries ', European Heart Journal-Cardiovascular Pharmacotherapy, vol. 6, no. 6, pp. 347-355 . https://doi.org/10.1093/ehjcvp/pvz038
Eroglu, T E, Mohr, G H, Blom, M T, Verkerk, A O, Souverein, P C, Torp-Pedersen, C, Folke, F, Wissenberg, M, van den Brink, L, Davis, R P, de Boer, A, Gislason, G H & Tan, H L 2020, ' Differential effects on out-of-hospital cardiac arrest of dihydropyridines : real-world data from population-based cohorts across two European countries ', European Heart Journal-Cardiovascular Pharmacotherapy, vol. 6, no. 6, pp. 347-355 . https://doi.org/10.1093/ehjcvp/pvz038
European Heart Journal-Cardiovascular Pharmacotherapy, 6(6), 347-355. OXFORD UNIV PRESS
European Heart Journal-Cardiovascular Pharmacotherapy, 6(6), 347-355. Oxford University Press
Eroglu, T E, Mohr, G H, Blom, M T, Verkerk, A O, Souverein, P C, Torp-Pedersen, C, Folke, F, Wissenberg, M, van den Brink, L, Davis, R P, de Boer, A, Gislason, G H, Tan, H L & ESCAPE-NET Investigators 2020, ' Differential effects on out-of-hospital cardiac arrest of dihydropyridines : real-world data from population-based cohorts across two European countries ', European heart journal. Cardiovascular pharmacotherapy, vol. 6, no. 6, pp. 347–355 . https://doi.org/10.1093/ehjcvp/pvz038
European Heart Journal — Cardiovascular Pharmacotherapy
European heart journal. Cardiovascular pharmacotherapy, 6, 347. NLM (Medline)
European heart journal. Cardiovascular pharmacotherapy, 6(6), 347-355. Oxford University Press
European Heart Journal-Cardiovascular Pharmacotherapy
ISSN: 2055-6837
2055-6845
Popis: Aims Various drugs increase the risk of out-of-hospital cardiac arrest (OHCA) in the general population by impacting cardiac ion channels, thereby causing ventricular tachycardia/fibrillation (VT/VF). Dihydropyridines block L-type calcium channels, but their association with OHCA risk is unknown. We aimed to study whether nifedipine and/or amlodipine, often-used dihydropyridines, are associated with increased OHCA risk, and how these drugs impact on cardiac electrophysiology. Methods and results We conducted a case–control study with VT/VF-documented OHCA cases with presumed cardiac cause from ongoing population-based OHCA registries in the Netherlands and Denmark, and age/sex/index date-matched non-OHCA controls (Netherlands: PHARMO Database Network, Denmark: Danish Civil Registration System). We included 2503 OHCA cases, 10 543 non-OHCA controls in Netherlands, and 8101 OHCA cases, 40 505 non-OHCA controls in Denmark. To examine drug effects on cardiac electrophysiology, we performed single-cell patch-clamp studies in human-induced pluripotent stem cell-derived cardiomyocytes. Use of high-dose nifedipine (≥60 mg/day), but not low-dose nifedipine ( Conclusion High-dose nifedipine, but not low-dose nifedipine or any-dose amlodipine, is associated with increased OHCA risk in the general population. Careful titration of nifedipine dose should be considered.
Databáze: OpenAIRE
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