Differential effects on out-of-hospital cardiac arrest of dihydropyridines:real-world data from population-based cohorts across two European countries
Autor: | Marieke T. Blom, Anthonius de Boer, Arie O. Verkerk, Patrick C. Souverein, Fredrik Folke, Hanno L. Tan, G H Mohr, Talip E Eroglu, Richard P. Davis, Mads Wissenberg, Lettine van den Brink, Gunnar Gislason, Christian Torp-Pedersen |
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Přispěvatelé: | Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Cardiology, Graduate School, ACS - Heart failure & arrhythmias, Medical Biology, Amsterdam Cardiovascular Sciences, APH - Methodology, APH - Health Behaviors & Chronic Diseases |
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
drug megadose induced pluripotent stem cell endogenous compound Epidemiology Denmark Action Potentials 030204 cardiovascular system & hematology Ventricular tachycardia low drug dose 0302 clinical medicine action potential Risk Factors Medicine Pharmacology (medical) Myocytes Cardiac AcademicSubjects/MED00200 030212 general & internal medicine Registries calcium current Cells Cultured Netherlands education.field_of_study cardiac muscle cell patch clamp technique Cardiac electrophysiology heart electrophysiology adult Sudden cardiac arrest Nifedipine Amlodipine drug effect Arrhythmia/Electrophysiology article titrimetry Middle Aged Calcium Channel Blockers 3. Good health female cardiovascular system Cardiology AcademicSubjects/MED00410 Female medicine.symptom Cardiology and Cardiovascular Medicine medicine.drug medicine.medical_specialty dihydropyridine out of hospital cardiac arrest Population Induced Pluripotent Stem Cells heart Risk Assessment sudden cardiac death 03 medical and health sciences male Internal medicine calcium channel L type Humans controlled study Calcium Signaling human out-of-hospital cardiac arrest education Aged Retrospective Studies Fibrillation Dose-Response Relationship Drug business.industry human cell Odds ratio Original Articles case control study nitric acid derivative medicine.disease ischemic heart disease major clinical study heart ventricle tachycardia business Out-of-Hospital Cardiac Arrest |
Zdroj: | Eroglu, T E, Mohr, G H, Blom, M T, Verkerk, A O, Souverein, P C, Torp-Pedersen, C, Folke, F, Wissenberg, M, Van Den Brink, L, Davis, R P, De Boer, A, Gislason, G H & Tan, H L 2020, ' Differential effects on out-of-hospital cardiac arrest of dihydropyridines : real-world data from population-based cohorts across two European countries ', European Heart Journal-Cardiovascular Pharmacotherapy, vol. 6, no. 6, pp. 347-355 . https://doi.org/10.1093/ehjcvp/pvz038 Eroglu, T E, Mohr, G H, Blom, M T, Verkerk, A O, Souverein, P C, Torp-Pedersen, C, Folke, F, Wissenberg, M, van den Brink, L, Davis, R P, de Boer, A, Gislason, G H & Tan, H L 2020, ' Differential effects on out-of-hospital cardiac arrest of dihydropyridines : real-world data from population-based cohorts across two European countries ', European Heart Journal-Cardiovascular Pharmacotherapy, vol. 6, no. 6, pp. 347-355 . https://doi.org/10.1093/ehjcvp/pvz038 European Heart Journal-Cardiovascular Pharmacotherapy, 6(6), 347-355. OXFORD UNIV PRESS European Heart Journal-Cardiovascular Pharmacotherapy, 6(6), 347-355. Oxford University Press Eroglu, T E, Mohr, G H, Blom, M T, Verkerk, A O, Souverein, P C, Torp-Pedersen, C, Folke, F, Wissenberg, M, van den Brink, L, Davis, R P, de Boer, A, Gislason, G H, Tan, H L & ESCAPE-NET Investigators 2020, ' Differential effects on out-of-hospital cardiac arrest of dihydropyridines : real-world data from population-based cohorts across two European countries ', European heart journal. Cardiovascular pharmacotherapy, vol. 6, no. 6, pp. 347–355 . https://doi.org/10.1093/ehjcvp/pvz038 European Heart Journal — Cardiovascular Pharmacotherapy European heart journal. Cardiovascular pharmacotherapy, 6, 347. NLM (Medline) European heart journal. Cardiovascular pharmacotherapy, 6(6), 347-355. Oxford University Press European Heart Journal-Cardiovascular Pharmacotherapy |
ISSN: | 2055-6837 2055-6845 |
Popis: | Aims Various drugs increase the risk of out-of-hospital cardiac arrest (OHCA) in the general population by impacting cardiac ion channels, thereby causing ventricular tachycardia/fibrillation (VT/VF). Dihydropyridines block L-type calcium channels, but their association with OHCA risk is unknown. We aimed to study whether nifedipine and/or amlodipine, often-used dihydropyridines, are associated with increased OHCA risk, and how these drugs impact on cardiac electrophysiology. Methods and results We conducted a case–control study with VT/VF-documented OHCA cases with presumed cardiac cause from ongoing population-based OHCA registries in the Netherlands and Denmark, and age/sex/index date-matched non-OHCA controls (Netherlands: PHARMO Database Network, Denmark: Danish Civil Registration System). We included 2503 OHCA cases, 10 543 non-OHCA controls in Netherlands, and 8101 OHCA cases, 40 505 non-OHCA controls in Denmark. To examine drug effects on cardiac electrophysiology, we performed single-cell patch-clamp studies in human-induced pluripotent stem cell-derived cardiomyocytes. Use of high-dose nifedipine (≥60 mg/day), but not low-dose nifedipine ( Conclusion High-dose nifedipine, but not low-dose nifedipine or any-dose amlodipine, is associated with increased OHCA risk in the general population. Careful titration of nifedipine dose should be considered. |
Databáze: | OpenAIRE |
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