The influence of GABA on the synthesis of N-acetylserotonin, melatonin, O-acetyl-5-hydroxytryptophol and O-acetyl-5-methoxytryptophol in the pineal gland of the male Wistar rat
| Autor: | M. G. M. Balemans, I. Smith, D. R. A. Mans, J. van Benthem |
|---|---|
| Přispěvatelé: | Revues Inra, Import |
| Rok vydání: | 1983 |
| Předmět: |
Male
Embryology medicine.medical_specialty Serotonin Indoles Time Factors O-acetyl-5-methoxytryptophol Medicine (miscellaneous) Biology In Vitro Techniques Pineal Gland Melatonin 03 medical and health sciences Norepinephrine Pineal gland chemistry.chemical_compound 0302 clinical medicine Internal medicine N-Acetylserotonin [SDV.BDD] Life Sciences [q-bio]/Development Biology medicine Animals Melatonin synthesis Incubation [SDV.BDLR] Life Sciences [q-bio]/Reproductive Biology gamma-Aminobutyric Acid 030304 developmental biology 0303 health sciences Acetylation Rats Inbred Strains Circadian Rhythm Rats [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition medicine.anatomical_structure Endocrinology Reproductive Medicine chemistry Hydroxytryptophol Animal Science and Zoology 030217 neurology & neurosurgery Developmental Biology Food Science medicine.drug |
| Zdroj: | Reproduction, nutrition, developpement. 23(1) |
| ISSN: | 0181-1916 |
| Popis: | The influence of GABA on the synthesis of N-acetylserotonin, melatonin, O-acetyl-5-hydroxytryptophol and O-acetyl-5-methoxytryptophol has been investigated using different experimental procedures. It was demonstrated that when GABA and an acetyl donor were added to the incubation medium together, a significant increase in synthesis of the N-acetylated products occurred during the night. Moreover there was a large increase in N-acetylserotonin synthesis at 15(00) hrs although none was observed in the control experiments. However, when GABA was added 20 min before the acetyl donor, synthesis of the N-acetylated products was significantly less. The opposite effect was observed for the O-acetylated indoles. These results confirm the proposal by Ebadi et al. (1982) that GABA, like norepinephrine, may be a regulator of melatonin synthesis. As melatonin is implicated in the regulation of reproduction it may be that GABA is equally significant in this regulatory effect. |
| Databáze: | OpenAIRE |
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