Levoamphetamine and dextroamphetamine: differential effect on aggression and hyperkinesis in children and dogs
| Autor: | L. Eugene Arnold, Elizabeth O'l. Corson, Vladimir Kirilcuk, Samuel A. Corson |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
medicine.medical_specialty
Dextroamphetamine Hostility Child Behavior Disorders Hyperkinesis Motor Activity Placebo Models Biological Placebos chemistry.chemical_compound Dogs Isomerism medicine Animals Humans Psychiatry Child Clinical Trials as Topic Behavior Animal Aggression Dopaminergic Psychiatry and Mental health Amphetamine Levoamphetamine chemistry Attention Deficit Disorder with Hyperactivity Evaluation Studies as Topic Anxiety medicine.symptom Psychology medicine.drug |
| Zdroj: | The American journal of psychiatry. 130(2) |
| ISSN: | 0002-953X |
| Popis: | In laboratory experiments with hyperkinetic, untrainable dogs and in a comparison of levoamphetamine, dextroamphetamine, and placebo in children, levoamphetamine and dextroamphetamine were found to be approximately equal in calming an aggressive, hostile dog and in benefiting "unsocialized-aggressive" children: dextroamphetamine was more effective than levoamphetamine in calming "nervousness" and hyperactivity in dogs and in overanxious-hyperkinetic children. These data suggest that in the hyperkinetic syndrome, aggression and hostility may be benefited equally by levoamphetamine or dextroamphetamine via a dopaminergic mechanism, while anxiety and overactivity may be benefited significantly only by the dextro isomer via a norepinephrinergic mechanism. |
| Databáze: | OpenAIRE |
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