Association of Renal Dysfunction With Remote Diffusion-Weighted Imaging Lesions and Total Burden of Cerebral Small Vessel Disease in Patients With Primary Intracerebral Hemorrhage
| Autor: | Xu-hua Xu, Xiang-hua Ye, Jin-song Cai, Ting Gao, Guo-hua Zhao, Wen-ji Zhang, Lu-sha Tong, Feng Gao |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Aging
medicine.medical_specialty Cognitive Neuroscience Renal function 030204 cardiovascular system & hematology urologic and male genital diseases Gastroenterology lcsh:RC321-571 03 medical and health sciences remote DWI lesions 0302 clinical medicine cystatin C renal dysfunction Internal medicine medicine lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Intracerebral hemorrhage glomerular filtration rate Proteinuria medicine.diagnostic_test biology cerebral small vessel disease business.industry Magnetic resonance imaging Odds ratio medicine.disease Hyperintensity Confidence interval Cystatin C biology.protein proteinuria medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Aging Neuroscience, Vol 10 (2018) |
| ISSN: | 1663-4365 |
| Popis: | Objective: Remote diffusion-weighted imaging (DWI) lesions (R-DWIL) found in intracerebral hemorrhage (ICH) patients are considered as an additional marker of cerebral small vessel disease (cSVD). This study aimed to investigate the association of renal dysfunction and R-DWIL, as well as the total burden of cSVD on magnetic resonance imaging among patients with primary ICH. Methods: One hundred and twenty-six consecutive patients were prospectively enrolled. R-DWIL on DWI, as well as other imaging markers of cSVD, including lacunes, white matter lesions, cerebral microbleeds, and enlarged perivascular spaces were rated using validated scales. Renal dysfunction was evaluated either by reduced estimated glomerular filtration rate (eGFR) or the presence of proteinuria or increased cystatin C. Results: After adjustments for potential confounders by logistic regression, impaired eGFR [odds ratio (OR) 6.00, 95% confidence interval (CI) 1.73-20.78], proteinuria (OR 3.07, 95% CI 1.25-7.54) and increased cystatin C (OR 2.73, 95% CI 1.11-6.72) were correlated with presence of R-DWIL. A similar association was also found between cystatin C levels (OR 3.16, 95% CI 1.39-7.19), proteinuria (OR 2.79, 95% CI 1.34-5.83) and the comprehensive cSVD burden. Conclusions: Renal dysfunction are associated with the presence of R-DWIL, and total burden of cSVD in patients with primary ICH. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|