Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels
| Autor: | Michael A Sundberg, Aurélia F. Porto, Silvane B. Santos, Edgar M. Carvalho, Márcia Lima, Glória Orge, Mirla Amorim, Andrea Bacellar, Fernanda Salles |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Treatment outcome Strongyloides stercoralis medicine Animals Humans Leukemia-Lymphoma Adult T-Cell IL-2 receptor Anthelmintics Human T-lymphotropic virus 1 biology Coinfection Tumor Necrosis Factor-alpha Public Health Environmental and Occupational Health Receptors Interleukin-2 General Medicine Original Articles Middle Aged biology.organism_classification medicine.disease Virology HTLV-I Infections Leukemia Infectious Diseases Strongyloidiasis Treatment Outcome Immunology Disease Progression Parasitology Tumor necrosis factor alpha Female |
| Popis: | Human T cell lymphotropic virus type 1 (HTLV-1) infection has been associated with recurrent and disseminated strongyloidiasis and adult T cell leukemia/lymphoma (ATLL).We compared immunological aspects and markers for ATLL in HTLV-1 patients with or without strongyloidiasis, and evaluated the influence of Strongyloides stercoralis treatment on the immune response and clinical outcomes of HTLV-1 infection.Levels of TNFα and IFNγ were lower in patients coinfected with HTLV-1 and S. stercoralis than in patients with HTLV-1 only (p0.05), and there was an increase in TNFα levels after anthelmintic treatment. Levels of sIL-2R were higher in patients with HTLV-1 coinfected with S. stercoralis and anthelmintic treatment decreased sIL-2R levels (p0.05). The one patient who developed ATLL was coinfected with S. stercoralis.These data show that helminthic infection has a modulatory role in HTLV-1 infection and that S. stercoralis may be a cofactor in the development of ATLL. |
| Databáze: | OpenAIRE |
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