Repeated stereotactic radiosurgery for recurrent brain metastases: An effective strategy to control intracranial oligometastatic disease
| Autor: | M. Gimeno Morales, P.D. Domínguez Echávarri, L.I. Ramos García, L. Arbea Moreno, P A Jablonska, D. Serrano Tejero, A. Calvo González, Marta Moreno-Jiménez, A. García-Consuegra, Ignacio Gil-Bazo, J. Aristu Mendioroz, S.M. Martín Pastor |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Radiosurgery 03 medical and health sciences 0302 clinical medicine medicine Humans In patient Oligometastatic disease Retrospective Studies Salvage Therapy Brain Neoplasms business.industry Cancer Hematology medicine.disease Brain disease Radiation therapy Treatment Outcome 030104 developmental biology Oncology 030220 oncology & carcinogenesis Toxicity Radiology Neoplasm Recurrence Local Whole brain radiation therapy business |
| Zdroj: | Critical Reviews in Oncology/Hematology. 153:103028 |
| ISSN: | 1040-8428 |
| DOI: | 10.1016/j.critrevonc.2020.103028 |
| Popis: | Due to improvements in systemic therapies and longer survivals, cancer patients frequently present with recurrent brain metastases (BM). The optimal therapeutic strategies for limited brain relapse remain undefined. We analyzed tumor control and survival in patients treated with salvage focal radiotherapy in our center. Thirty-three patients with 112 BM received salvage stereotactic radiosurgery (SRS) or fractionated stereotactic radiotherapy (FSRT) for local or regional recurrences. Local progression was observed in 11 BM (9.8 %). After 1 year, 72 % of patients were free of distant brain failure, and the 2-year overall survival (OS) was 37.7 %. No increase in toxicity or neurologically related deaths were observed. The 2- and 3-year whole brain radiation therapy free survival (WFS) rates were 92.9 % and 77.4 %, respectively. Hence, focal radiotherapy is a feasible salvage of recurrent BM in selected group of patients with limited brain disease, achieving a maintained intracranial control and less neurological toxicity. |
| Databáze: | OpenAIRE |
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