Increased epicardial fat thickness in sudden death from stable coronary artery atherosclerosis
| Autor: | R. Beh, Jack Garland, Rexson Tse, Sravan Anne, Dennis McNevin, Belinda Fuller |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Computed tomography Disease Coronary Artery Disease 030204 cardiovascular system & hematology Sudden death Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Internal medicine Pathology medicine Humans 030212 general & internal medicine Normal heart Retrospective Studies Aged Aged 80 and over medicine.diagnostic_test business.industry 1103 Clinical Sciences Retrospective cohort study Coronary artery atherosclerosis Middle Aged Epicardial fat Death Sudden Cardiac Adipose Tissue Cardiology Female Legal & Forensic Medicine Ischemic heart business Tomography X-Ray Computed Pericardium |
| Popis: | Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved. Background: Sudden death from stable coronary artery atherosclerosis (SCAA) is well recognized. However, individuals can have ischemic heart disease or coronary artery atherosclerosis but die of noncardiac causes. Recently, it has been recognized that increased epicardial fat is detrimental to normal heart function. We hypothesize that individuals who die of SCAA have increased epicardial fat. Aim: The aim of this study was to investigate whether there is an increase in epicardial fat in individuals who suddenly died of SCAA. Methods: This was a 1-year retrospective study comparing the average epicardial fat thickness using postmortem computed tomography scan between individuals who suddenly died of SCAA (SCAA group) with individuals who primarily died of natural noncardiac causes but had established ischemic heart disease or significant coronary artery atherosclerosis (NCC group). Results: Average epicardial fat thickness was significantly higher in the SCAA group (8 ± 2 mm) than in the NCC group (6 ± 2 mm, P = 0.008). Conclusions: Individuals who die of SCAA appear to have higher epicardial fat thickness. The increase in epicardial fat may have an additional detrimental effect to the heart predisposing sudden death in individuals with coronary artery atherosclerosis. |
| Databáze: | OpenAIRE |
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