Modulation of aflatoxin B1-induced glutathione S-transferase placental form positive hepatic foci by pretreatment of rats with phenobarbital and buthionine sulfoximine
| Autor: | Kiyoko Lehmann, Hisashi Shinozuka, Prabhakar D. Lotlikar, Prathima Gopalan, Kiyomi Sato, Masatomo Kimura, Kojiro Tsuji |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Pathology Aflatoxin Antimetabolites Antineoplastic Aflatoxin B1 Biology chemistry.chemical_compound Internal medicine Methionine Sulfoximine medicine Animals Buthionine sulfoximine Drug Interactions Enzyme inducer Buthionine Sulfoximine Glutathione Transferase General Medicine Glutathione DNA Rats Inbred F344 Rats Endocrinology Glutathione S-transferase chemistry Liver Enzyme Induction Phenobarbital Toxicity biology.protein Immunohistochemistry medicine.drug |
| Zdroj: | Carcinogenesis. 14(7) |
| ISSN: | 0143-3334 |
| Popis: | Induction of glutathione S-transferase placental form (GST-P) positive hepatic foci has been examined by immunohistochemical analysis in young male Fischer rats 3 weeks after a single i.p. injection of aflatoxin B1 (AFB1). Pretreatment of rats with L-buthionine sulfoximine (BSO), a GSH depleter, at a dose of 4 mmol/kg body wt 4 and 2 h before 1.0 mg AFB1 treatment enhanced both the number of AFB1-induced hepatic foci and the area occupied by these foci by approximately 400 and 575% above their respective controls without affecting the mean diameter of these foci. Pretreatment of rats with 0.1% phenobarbital (PB) in their drinking water for 1 week before AFB1 (1 mg) treatment, inhibited AFB1-induced foci almost completely. However, the number of AFB1-induced foci in PB-pretreated rats was not significantly increased by BSO pretreatment. |
| Databáze: | OpenAIRE |
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